摘要
表观遗传学是指DNA序列不发生变化的情况下基因表达发生的可遗传的改变。大量的研究发现,表观遗传机制参与调控糖尿病肾病的肾脏纤维化、足细胞凋亡、慢性炎性反应、氧化应激等各个病理生理过程。
Epigenetics refers to the heritable alteration of gene expression without the change of DNA sequence. Emerging evidence from research suggests a key role for epigenetic mechanisms in the regulation of physiological and pathological processes of diabetic nephropathy including renal fibrosis, podocyte apoptosis, chronic inflammation, oxidant stress and so on.
出处
《国际内分泌代谢杂志》
2017年第1期48-51,共4页
International Journal of Endocrinology and Metabolism
基金
上海市科学技术委员会科研计划项目(14ZR1427400)
关键词
糖尿病肾病
表观遗传学
调控
Diabetic nephropathy
Epigenetics
Regulation