血浆25-羟维生素D水平与2型糖尿病合并脑梗死的关系

Relationship between plasma 25- hydroxy vitamin D level and type 2 di-abetes mellitus complicated with cerebral infarction

目的探讨血浆25-羟维生素D[25(OH)Vit D]水平与2型糖尿病(T2DM)合并脑梗死的关系。方法选取2015年1月~2016年6月我院住院就诊的120例T2DM患者,检测血脂、糖化血红蛋白C(Hb A1c)等血液生化指标,用ELISA法测定血浆25(OH)Vit D的浓度。根据头颅CT或MRI结果,按是否合并脑梗死分为T2DM无脑梗死组(DNCI组)64例和T2DM脑梗死组(DCI组)56例,分析两组25(OH)Vit D水平与T2DM合并脑梗死的关系。结果两组患者的性别、体重指数(BMI)、糖尿病病程、收缩压(SBP)、舒张压(DBP)、餐后2 h血糖(2 h PG)比较,差异无统计学意义(P>0.05)。DCI组患者年龄、空腹血糖(FPG)、Hb A1c、颈动脉斑块率显著高于DNCI组,血浆25(OH)Vit D浓度显著低于DNCI组,差异有统计学意义(P<0.05)。Logistic回归分析提示,25(OH)Vit D是糖尿病合并脑梗死的独立保护因素(风险比为0.84,95%CI 0.72~0.97,P<0.05),而颈动脉斑块是糖尿病合并脑梗死的独立危险因素(风险比为1.23,95%CI 1.11~1.36,P<0.05)。结论血浆25(OH)Vit D是糖尿病合并脑梗死患者的独立保护因素。

Objective To explore relationship between serum plasma 25 hydroxy vitamin D [25（OH）VitD] level and type 2 diabetes mellitus （T2DM） complicated with cerebral infarctlon.Methods 120 patients with T2DM hospitalized in our hospital from January 2015 to June 2016 were selected.Serum lipids,glycated hemoglobin C （HbAlc） and other blood biochemical parameters were detected by automatic biochemical analyzer,plasma 25（OH）VitD level was measured by ELISA.According to brain CT or MRI results,patients with T2DM were divided into with cerebral infarction group （DCI group） or no cerebral infarction group （DNCI group）,relationship between plasma 25（OH）VitD level and T2DM compli- cated with cerebral infarction was analyzed.Results The difference between two groups of gender,body mass index （BMI）,duration of diabetes mellitus,systolic blood pressure （SBP）,diastolic blood pressure （DBP） and 2-hour postprandial blood glucose （2 h PG） was not statistically significant （P〉0.05）.However,age,fasting plasma glucose （FPG）,glycosylated hemoglobin （HbAlc）,carotid artery plaque rate in DCI group was significantly higher than that in DNCI group,while plasma 25（OH）VitD level was significantly lower than that in DNCI group （P〈0.05）.Logistic regression analysis showed that 25（OH）VitD was an independent protective factor for T2DM complicated with cerebral infarction patients （OR 0.84,95%CI 0.72-0.97,P〈0.05）,and carotid plaque was an independent risk factor for T2DM complicated with cerebral infarction patients （OR 1.23,95%CI 1.11-1.36,P〈0.05）.Conclusion Plasma 25（OH）VitD is an independent protective factor for T2DM complicated with cerebral infarction patients.