黄芪注射液联合常规西药治疗老年慢性充血性心力衰竭临床观察

Clinical Observation of Astragalus Injection Combined with Conventional Western Medicine for Senile Patients of Chronic Congestive Heart Failure

目的:观察黄芪注射液联合常规西药治疗老年慢性充血性心力衰竭(CHF)心气虚、血脉瘀阻证的临床疗效。方法:将90例慢性CHF心气虚、血脉瘀阻证老年患者按随机数字表法分为观察组和对照组各45例。对照组给予常规西药治疗,观察组在对照组用药基础上联合黄芪注射液治疗。观察2组症状、体征,以及心功能的改善情况。结果:观察组治疗总有效率95.56%,高于对照组的82.22%(P<0.05)。治疗后,观察组心功能的改善情况优于对照组(P<0.05)。治疗前,2组左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)和左心室射血分数(LVEF)比较,差异均无统计学意义(P>0.05)。治疗后,2组LVEDV、LVESV和LVEF均较治疗前改善,差异均有统计学意义(P<0.05);观察组LVEDV、LVESV和LVEF的改善情况均优于对照组,差异均有统计学意义(P<0.05)。结论:黄芪注射液联合常规西药治疗慢性CHF心气虚、血脉瘀阻证,能有效改善患者的症状、体征及心功能,疗效优于单纯使用常规西药治疗。

Objective：To observe the clinical effect of astragalus injection combined with conventional western medicine in treating senile patients with heart-qi deficiency syndrome and blood stasis syndrome of chronic congestive heart failure（CHF）.Methods：Divided 90 cases of patients with heart-qi deficiency syndrome and blood stasis syndrome of CHF into the observation group and the control group randomly,45 cases in each group.The conventional western medicine treatment was given to both groups,and the observation group received additional treatment of astragalus injection.Observed improvements on symptoms,physical signs and cardiac function in two groups.Results：The total effective rate in the observation group was 95.56%,being higher than 82.22%of the control group（P〈0.05）.The improvement in the observation group was superior to that in the control group（P〈0.05）.Before treatment,compared left ventricular end-diastolic volume（LVEDV）,left ventricular end-systolic volume（LVESV） and left ventricular ejection fraction（LVEF） between two groups,there was no significance in differences（P〉0.05）.After treatment,LVEDV,LVESV and LVEF were all improved,differences being significant（P〈0.05）.The improvement in the observation group was superior to that in the control group,showing significance in differences（P〈0.05）.Conclusion：The therapy of astragalus injection combined with conventional western medicine for senile patients with heart-qi deficiency syndrome and blood stasis syndrome of CHF can evidently improve symptoms,physical signs and cardiac function.It has better curative effect than conventional western medicine.