中西医结合治疗冷哮型急性支气管哮喘50例临床观察

Clinical Observation of Integrated Chinese and Western Medicine Therapy for Acute Bronchial Asthma of Cold Type:A Report of 50 Cases

目的:观察中西医结合治疗冷哮型急性支气管哮喘患者的临床疗效。方法:选取100例冷哮型急性支气管哮喘患者,随机分为对照组和研究组各50例。2组均予沙丁胺醇气雾剂、氨茶碱注射液等对症治疗,研究组再予射干麻黄汤加减治疗。观察2组治疗前后症状总积分、超敏C-反应蛋白(hs-CRP)、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量百分比(FEV_1/FVC%)]的变化及用药安全性。结果:总有效率研究组98.0%,对照组86.0%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组症状总积分及hs-CRP水平均较治疗前降低(P<0.01);研究组症状总积分及hs-CRP水平均低于对照组(P<0.05)。研究组FEV_1、FVC、FEV_1/FVC%值均高于对照组(P<0.05)。2组患者在治疗过程中均未见严重的不良反应事件发生。结论:中西医结合治疗冷哮型急性支气管哮喘患者安全有效,能提高临床疗效,有效改善患者的肺功能。

Objective：To observe the clinical effect of Chinese medicine combined with western medicine in treating patients with acute bronchial asthma of cold type.Methods：Selected 100 patients with acute bronchial asthma of cold type and divided them into the control group and the research group randomly,50 cases in each group.The two groups were both given the symptomatic treatment such as salbutamol aerosols,aminophylline injection,etc.,and the research group was additionally given the therapy of Shegan Mahuang tang.Compared total scores of symptoms and changes of high sensitive C-reactive protein（hs-CRP）,lung function[forced expiratory volume in 1 second（FEV1）,forced vital capacity（FVC） and first second forced expiratory volume accounting for the percentage of forced expiratory volume（FEV1/FVC%）]as well as safety of the two groups before and after treatment.Results：The total effective rate was 98.0%in the research group and 86.0%in the control group,the difference being significant（P〈0.05）.After treatment,total scores of symptoms and hs-CRP levels in two groups were lower than those before treatment（P〈0.01）.Scores of symptoms and hs-CRP levels in the research group were lower than those in the control group（P〈0.05）.FEV1,FVC,FEV1/FVC%in the research group were all higher than those in the control group（P〈0.05）.There was no severe adverse reaction in two groups during treatment.Conclusion：Integrated Chinese and western medicine therapy for treating patients with acute bronchial asthma of cold type is safe and effective,which can enhance the clinical effect and improve lung function.