葛芪二补汤对颈椎退行性病变患者炎性因子及血液黏度的影响

Effect of Geqi Erbu Tang on Inflammatory Factors and Blood Viscosity for Patients with Cervical Degenerative Disease

目的:探讨葛芪二补汤对颈椎退行性病变患者炎性因子及血液黏度的影响。方法:将80例颈椎退行性病变患者采用随机数字表法分为2组各40例。对照组行常规治疗,观察组在常规治疗基础上加用葛芪二补汤。比较2种治疗方法治疗效果及对患者炎性因子及血液黏度的影响。结果:总有效率观察组97.50%,对照组为85.00%,2组比较,差异有统计学意义(P<0.05)。2组治疗后白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)及肿瘤坏死因子-α(TNF-α)水平较治疗前均降低,差异有统计学意义(P<0.05)。治疗后观察组IL-6、IL-1β及TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。2组治疗后高切全血黏度、低切全血黏度、还原高切及还原低切水平较治疗前均降低(P<0.05)。治疗后观察组上述各指标均低于对照组(P<0.05)。结论:葛芪二补汤治疗颈椎退行性病变效果显著,可能与葛芪二补汤抑制炎性因子表达、改善血液黏度有关。

Objective：To observe the effect of Geqi Erbu tang on inflammatory factors and blood viscosity in patients with cervical degenerative disease.Methods：Divided 80 cases of patients with cervical degenerative disease into two groups randomly,40 cases in each group.The conventional treatment was given to both groups,and the observation group received additional treatment of Geqi Erbu tang.Compared the clinical effect of two therapies on patients＇ inflammatory factors and blood viscosity.Results：The total effective rate was 97.50%in the observation group and 85.00%in the control group,the difference being significant（P〈0.05）.After treatment,levels of interleukin-6（IL-6）,interleukin-1β（IL-1β）and tumor necrosis factor-a（TNF-α） in both groups were all decreased（P〈0.05）.After treatment,levels of IL-6,IL-1β and TNF-α in the observation group were all lower than those in the control group（P〈0.05）.Levels of high shear blood viscosity,low shear blood viscosity,high shear reduction and low shear reduction in both groups were declined after treatment（P〈0.05）.All indexes above in the observation group were lower than those in the control group（P〈0.05）.Conclusion：The therapy of Geqi Erbu tang for patients with cervical degenerative disease has remarkable effect,and it maybe related to the expression of inflammatory factors and the improvement of blood viscosity.