2Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition [ J ]. Pharmacol Rev, 2004, 56(3) :387-437.
3Collantes E, Curtis SP, Lee KW. A multinational randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis[ J]. BMC Fam Pract, 2002, 22(3) :452-462.
4Scheiman JM, Yeomans ND, Talley N J, et al. Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors[J]. Am J Gastroenterol, 2006, 101 (4) :701- 710.
5Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib versus nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib Long-term Arthritis Safety Study [ J]. JAMA, 2000, 284(10) : 1247-1255.
6Winkelmayer WC, Waikar SS, Mogun H. Nonselective and cyclooxygenase-2-selective NSAIDs and acute kidney injury[ J]. Am J Med, 2008, 121 (12) :1092-1098.
7Patrignani P. Nonsteroidal anti-inflammatory drugs, COX-2 and colorcctal cancer[ J]. Toxicol Lett, 2000, 112-113:493-498.
8Brune K, Hinz B. Selective cyclooxygenase-2 inhibitors : similarities and differences[Jl. Scand J Rheumatol, 2004, 33:1-6.
9Langenbach R, Morham SG, Tiano HF, et al. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acidinduced inflammation and indomethacin-induced gastric ulceration [ J J. Cell, 1995, 83(3) :483-492.
10Wallace JL, McKnight W, Reuter BK. NSAID-induced gastric damage in rats : requirement for inhibition of both cyclooxygenase 1 and 2 [ J ]. Gastroenterology, 2000, 119 ( 3 ) :706-714.
