红曲复方治疗乙型肝炎肝硬化的疗效观察

Effect of Hongqu Decoration in treating the Hepatitis B Cirrhosis

目的:研究红曲复方治疗乙型肝炎肝硬化的疗效。方法:80例乙型肝炎肝硬化患者,采用随机数字表法将患者分为对照组和观察组,各40例。对照组采用拉米夫定治疗,观察组在对照组的基础上,给予红曲复方治疗。观察两组患者的临床表现改善情况,采用中医证候评分进行评价。检测治疗前后血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、干扰素(IFN)-γ与白介素(IL)-8浓度水平。结果:观察组患者总有效率82.50%高于对照组57.50%,差异有统计学意义(P<0.05)。治疗后,两组患者血清ALT与AST含量均明显低于治疗前,差异有统计学意义(P<0.05)。观察组患者治疗后血清ALT含量明显低于对照组,差异有统计学意义(P<0.05);而观察组患者治疗后血清AST含量略低于对照组,差异无统计学意义(P>0.05)。治疗后,观察组患者血清IFN-γ与IL-8含量均明显低于对照组,差异有统计学意义(P<0.05)。结论:红曲复方能够显著改善乙型肝炎肝硬化患者临床症状,具有显著降低ALT作用,而其主要通过减少IFN-γ与IL-8的分泌从而实现护肝抑炎作用。

Objective To investigate the effect of Hongqu decoration in treating the hepatitis B cirrhosis. Methods 80 patients with hepatitis B cirrhosis were randomly divided into control and observation group and there were 40 in each. Patients in control group were treated with lamivudine while Hongqu decoration was additionally given in the observation group. The manifestations were observed with the TCM symptom complex score. The serum concen- trations of alanine aminotransferase（ ALT）, aspartate aminotransferase（ AST）, interferon （IFN） - γ and intedeukin（IL） -8 were tested. Results The total effective rate of the observation group was 82. 50% higher than that of the control group 57.50%, and the difference was statistically significant （P 〈 0. 05）. After treatment, the serum levels of ALT and AST in the two groups were significantly lower than those before treatment, the difference was statistically significant （ P 〈 0.05 ）. To observe the content of serum ALT of patients after treatment was significantly lower than the control group, the difference was statistically significant （P 〈 O. 05 ） ; while the patients in the observation group after treatment serum AST content was slightly lower than that of the control group, the difference was not statistically significant （ P 〉 0. 05 ）. After treatment, the serum levels of IFN - γ and IL - 8 in the obser- vation group were significantly lower than those in the control group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Hongqu decora- tion could improve the signs and symptoms of hepatitis B cirrhosis, which could not just decreuse the ALT, but it could also protect the liver and be anti - inflammatory by the mechanism on reducing the IFN - γand IL - 8.