新疆维吾尔族人群MTHFR基因与非酒精性脂肪肝的相关因素分析

Association of MTHFR gene polymorphisms and non-alcoholic fatty liver among ethnic Uyghurs

目的探讨新疆维吾尔族人群5,10-亚甲基四氢叶酸还原酶(5,10-methylenetetrahydrofolate reductase,MTHFR)基因多态性与非酒精性脂肪肝(NAFLD)的相关因素。方法采用病例-对照研究,对维吾尔族NAFLD患者(NAFLD组,325例)和非NAFLD组(304例)MTHFR基因的rs1801131和rs1801133位点进行基因分型,用Logistic回归分析rs1801131和rs1801133位点多态性与新疆维吾尔族人群NAFLD的关系。结果在rs1801133基因位点的隐性模型中,AA基因型在NAFLD的发生过程中是风险因素(OR=2.023,P=0.033),在加性模型和显性模型下的基因型的分布差异无统计学意义(P<0.05)。在rs1801131基因位点的加性模型、显性模型和隐性模型下的基因型的分布差异无统计学意义(P>0.05)。结论维吾尔族人群中MTHFR基因rs1801133基因位点多态性与NAFLD的发生有关,AA基因型可能增加NAFLD的发病风险。

Objective To discuss the relationship between Methylenetetrahydrofolate reductase （MTHFR） genes polymorphism and non-alcohonic fatty liver disease NAFLD in Uyghurs from Xinjiang. Methods U- sing case-control study, the MTHFR gene rs1801131 and rs1801133 coming from 325 Uyghurs patients with NAFLD and 304 Uyghurs non-NAFLD were genotyped. The relationship between the rs1801133 pol- ymorphism and NAFLD was analysed by logistic regression analysis. Results In rs1801133 locus recessive model, AA genotype in the pathogenesis of NAFLD was the factor （P =0.033 and OR =2.023）. There are no statistical significance in the distribution of genotypes in the additive and dominant models （P 〈0.05）. There was no statistical significance （P〉0.05） in the additive model, dominant model and recessive model of the rs1801131 gene locus. Conclusion The MTHFR gene polymorphism of rs1801133 gene is related to the occurrence of NAFLD, and the AA genotype may increase the risk of NAFLD.