哈萨克族食管鳞癌组织中SM22α的表达及其临床意义

Expression of SM22α in esophageal squamous cell carcinoma of Kazak and its clinical significance

目的探讨哈萨克族食管鳞癌组织中SM22α的表达情况及其临床意义。方法用免疫组织化学技术对筛选出的食管鳞癌组织中的差异蛋白SM22α进行验证,并结合临床病理参数对162例石蜡包埋食管鳞癌组织及50例食管黏膜正常组织中SM22α表达情况进行分析。结果SM22α在食管鳞癌组织中的阳性表达率(87.0%)高于食管正常黏膜组织(36.0%),差异有统计学意义(P<0.05);浸润深度(χ~2=8.078,P=0.044)、淋巴结是否转移(χ~2=6.420,P=0.012)与SM22α在食管鳞状细胞癌肿瘤组织中阳性表达存在相关性(P<0.05)。结论 SM22α可能参与了食管鳞状细胞癌的发生、发展。

Objective To analyze the expression of SM22a in esophageal squamous cell carcinoma of Kazak and Han nationalities, According to the clinical pathological parameters to screen molecular markers. Methods Immunohistochemical method was used to detect the expressions of SM22α in 162 cases of ESCC and 50 cases of normal esophageal tissues, and their correlations to the clinicopathologic characteristics of ESCC were analyzed. Results Immunohistochemistry verified the expression of differences, suggesting that the positive expression rate of SM22α in cancer tissues was higher than that of normal mucosa （P〈0.05）; SM22α expression positive and infiltration depth （P〈0.05）, lymph node metastasis （P〈0.05）, there is a correlation; Conclusion SM22α is an important molecular changes in the development of esophageal squamous cell carcinoma.