2[1]Oldfield EH. Gene therapy for the treatment of braintumors using intra-tumoral transduction with the thymi-dine kinase gene and intravenous ganciclovir. HumanGene Therapy,1993,4:39
3[2]Fueyo J,Gomez-Manzano C,Yung WK et al. Targe-ting in gene therapy of glioma. Arch Neurol,1999,56:445
4[3]Hesdorffer C,Ayello J,Ward M et al. Phase I trial ofretroviral-mediated transfer of the human MDR1 geneas marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplan-tation. J Clin Oncol,1998,16:165
5[4]Klatzmann D,Valery CA,Bensimon G et al. A phaseI/II study of herpes simplex virus type 1 thymidine ki-nase ″suicide″gene therapy for recurrent glioblastoma.Hum Gene Ther,1998,20:2595
6[5]Ram Z,Culver KW,Oshiroz EM et al. Therapy ofmalignant brain tumor by intratumoral implantation ofretroviral vector-producing cells. Nature Med,1997,3:1354
7[6]Palu G,Cavaggioni A,Calvi P et al. Gene therapy ofglioblastoma multiforme via combined expression of sui-cide and cytokine genesa pilot study in human. GeneTherapy,1999,6:330
8[7]Colombo F,Zanusso M,Casentini L et al. Gene Stere-otactic neurosurgery for recurrent malignant gliomas.Stereotact funct Neurosurg,1997,68:245
9[8]Stockhammer G,Brotchi J,Leblanc R et al. Gene th-erapy for glioblastoma multiforme:in vivo tumor transd-uction with the herpes simplex thymidine kinase genefollowed by ganciclovir. J Mol Med,1997,75:300
10[9]Shand N,Weber F,Mariani L et al. A phase 1-2clinical trial of gene therapy for recurrent glioblastomamultiforme by tumor transducton with the herpes simp-lex thymidine kinase gene followed by ganciclovir. GLI-328 European-Canadian study group. Hum Gene Ther,1999,10:2325