康莱特注射液联合新辅助化疗方案治疗肺癌的疗效及其对细胞凋亡和增殖的影响

The efficacy of Kanglaite injection combined with neoadjuvant chemotherapy in the treatment of lung cancer and its effects on cell apoptosis and proliferation

目的:探讨康莱特注射液联合新辅助化疗方案治疗肺癌的临床疗效及其对细胞凋亡和增殖的影响。方法:回顾性分析新辅助化疗的90例确诊肺癌患者的临床资料,根据是否联用康莱特注射液将其分为联合组(n=40)和对照组(n=50),所有患者均行肺叶或全肺切除术加纵隔淋巴结清扫术。观察两组患者治疗前、后T细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、细胞增殖水平[Ki-67指数(KI)]和细胞凋亡水平[凋亡指数(AI)]变化情况,比较两组临床疗效及2年复发率、转移率和病死率。结果:联合组总有效率为75.0%,明显高于对照组的48.0%(P<0.05)。治疗后,联合组CD3^+、CD4^+、CD8^+水平及CD4^+/CD8^+比值均较对照组明显升高(P<0.05)。联合组治疗后KI较对照组降低,AI较对照组升高(均P<0.05)。两组2年复发率、转移率和病死率比较,差异均无统计学意义(均P>0.05)。结论:康莱特注射液联合新辅助化疗方案应用于肺癌患者可提高疗效,并对机体免疫功能及癌细胞凋亡、增殖等具有调节作用。

Objective： To investigate the efficacy of Kanglaite injection combined with neoadjuvant chemotherapy in the treatment of lung cancer and its effects on cell apoptosis and proliferation. Methods： 90 patients diagnosed with lung cancer who underwent neoadjuvant chemotherapy were selected and divided into a combination group （ n =40） and a control group （ n =50） according to whether administrated with Kanglaite injection. All patients received lobectomy or pneumonectomy with systematic mediastinal lymphadenectomy. The percentages of CD3^＋ , CD4^＋ and CD8^＋ T-cell subsets, cell proliferation and apoptosis before and after treatment as well as the clinical efficacy, 2-year recurrence rate, metastasis rate and mortality were compared between the two groups. Results： The total response rate in the combination group was significantly higher than that in the control group （75.0G vs. 48.0%, P 〈0.05）. After treatment, the percentages of CD3^＋, CD4^＋ and CD8^＋ T-cell subsets and CD4^＋/CD8^＋ ratio in the combination group were higher than those in the control group （ P d0.05）. The positive rate of Ki-67 expression was decreased, while the apoptosis index was increased in the combination group, as compared with the control group （ P 〈0.05）. There were no statistical differences in 2-year recurrence rate, metastasis rate and mortality between the two groups（ P 〉0.05）. Conclusion： Kanglaite injection combined with neoadjuvant chemotherapy achieved a significant effect on treatment of lung cancer. This combination could improve patients＇ immune function and regulate apoptosis and proliferation of cancer cells.