摘要
成纤维细胞生长因子21(FGF21)是近几年新发现的代谢调节因子,它与糖尿病性大血管病变之间的关系已成为近些年的研究热点。内源性FGF21水平在糖耐量受损时升高,随着2型糖尿病大血管病变的出现,其水平进一步升高,推测其可能机制是FGF21抵抗。血管内皮细胞有FGF21基因表达,且FGF21在动脉粥样硬化早期可能起保护作用,这暗示着FGF21有望成为预防和治疗糖尿病性大血管病变的靶点。
Fibroblast growth factor 21（ FGF21） is a newly discovered metabolic regulatory factor in recent years.The relationship between FGF21 and diabetic macroangiopathy has become a research hotspot in recent years. The level of endogenous FGF21 is increased in patients with impaired glucose tolerance,and its level is progressively increased with the appearance of type 2 diabetes mellitus with macroangiopathy. It is speculated that the possible mechanism is FGF21 resistance. FGF21 gene is expressed in vascular endothelial cells,and FGF21 may play a protective role in the early stage of atherosclerosis,suggesting that FGF21 is expected to become a target for prevention and treatment of diabetic macroangiopathy.
出处
《中国动脉硬化杂志》
CAS
北大核心
2017年第1期95-98,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(80214020)
