血浆纤维蛋白原和D-二聚体与肺栓塞复发的相关性研究

Relationship between the Plasma Fibrinogen and D- dimer and Recurrence of Pulmonary Embolism

目的：探讨血浆纤维蛋白原（FIB）和D-二聚体（D-D）与肺栓塞复发之间的关系。方法：选择我院收治的肺栓塞初次治疗缓解后患者115例作为初治缓解组，其中37例出现肺栓塞复发作为复发组，78例未复发者作为未复发组，观察并比较各组间的FIB和D-D水平变化。结果：肺栓塞复发组患者血浆FIB和D-D水平高于初治缓解组和未复发组患者的FIB和D-D水平，差异均具有显著统计学意义（均P〈0．01）。单侧复发组与双侧复发组血浆FIB和D-D水平比较均无明显统计学差异（均P〉0．05）；复发难治组患者血浆FIB和D-D水平均高于复治改善组，差异有显著统计学意义（均P〈0．01）。结论：FIB和D-D的升高与肺栓塞复发关系密切，对肺栓塞复发的预测、诊断、治疗及疗效判断有重要临床意义。

OBJECTIVE ： To explore the ralationship between the plasma fibrinogen （FIB） and D - dimer （ D - D） and the re- currence of pulmonary embolism, METHODS： 115 patients with initial pulmonary embolism were divided into the recurrence group （ n = 37 ） and the non - recurrence group （ n = 78 ）. The levels of FIB and D - D were observed in the two groups. RESULTS ： The levels of FIB and D - D were higher in the recurrence group than those in the non - recurrence group. There was significant difference （ P 〈 0. 01 ）. There was no significant statistically difference in the levels of FIB and D - D between unilateral recurrence group and bi- lateral recurrence group （P 〉 0. 05）. The levels of FIB and D - D were higher in the recurrence refractory group than those in the re- treatment improve group. There was statistically significant difference （P 〈 0. 01 ）. CONCLUSIONS： The elevated levels of FIB and D- D are closely related to pulmonary embolism recurrence. The result above plays the important in the forecast, diagnosis, treat- ment and curative effect of puhnonary embolism recurrence.