尿促性素诱发肺血栓栓塞症1例并文献复习

Pulmonary thromboembolism induced by Menotrophin:a case report and literature review

目的提出育龄期妇女发生肺血栓栓塞症的一个新的独立危险因素。方法对1例育龄期不孕女性应用促排卵针注射用尿促性素(Menotrophin for Injection)2个月后发生急性肺血栓栓塞症的病例进行分析讨论并阅读相关文献进行分析总结。结果该患者不存在肿瘤、下肢静脉血栓、免疫系统疾病、易栓症、妊娠、分娩、口服避孕药、骨折制动等育龄期妇女常见诱发肺栓塞的高危因素。结论促排卵针注射用尿促性素为育龄期妇女发生肺血栓栓塞症的高危因素因其改变机体内环境的激素水平,其辅料甘露醇及注射用绒促性素(HCG)可能起协同作用。

Objective To propose a new independent risk factor for pulmonary embolism in women of childbearing age.Methods To analyse a case of acute pulmonary embolism after the use of Menotrophin for injection 2 month later in infertile women of childbearing age,and to summary after reading related literature.Results This patient didn＇t have the comon high risk factors of pulmonary embolism in women of childbearing age,such as cancer,deep venous thrombosis,immune system disease,thrombophilia,pregnancy,delivery,oral contraceptives,fractures of the brake and so on.Conclusion Menotrophin for injection is a high risk factor for pulmonary embolism in women of childbearing age.Because it can change internal environmental hormone levels,its accessories mannitol and HCG may play a synergistic effect.