抗生素药物与人类肠道菌群关系的研究现状

Current research on the relationship between antimicrobial agents and human intestinal flora

人类肠道内菌群为人体内最大的内毒素池人体本身因素、外界环境因素及菌群自身因素对肠道菌群的动态平衡均有着不同的影响,当肠道菌群的动态平衡失衡时人类健康将造成危害。抗生素的应用恢复肠道菌群的失衡在一定程度上起着不可或缺的作用,但抗生素药物影响致病菌的同时,也会影响肠道内的正常菌群。对肠道内细菌菌群的影响以及影响的程度,取决于相关抗生素药物的抗菌谱系、给药的途径(口服、静脉、体外等)、给药的方式、肠道内抗生素药物的浓度等。肠道内菌群之间的相互作用也影响着抗生素药物对机体所起的作用道本身也是人体内最大的免疫器官,如抗生素药物与肠道菌群之间可以达到最佳的相互作用,将对人类健康的影响起着至关重要的作用。

Intestinal flora is the body＇s largest endotoxin pool.The factors of body,external environment and intestinal flora have different effects on the dynamic equilibrium of the intestinal flora.The dynamic imbalance of intestinal flora will cause harm to human health.To restore the imbalance of intestinal flora,the use of anti bacterium plays an indispensable role in a certain extent.The antimicrobial will affect intestinal pathogen and the same to the intestinal normal flora.The effect on intestinal bacterial flora of antimicrobial agents and the influence degree are related to antibiotics antibacterial spectrum,route of administration（oral,vein,in vitro,etc.）,administration mode,the concentration of intestinal antimicrobial agents,and so on.The interaction between the intestinal flora also affects the antimicrobial effect of body.The intestinal itself is the biggest immune organs.If antibacterial agents and intestinal flora can achieve optimum interaction,it will play a vital role to human health.