启肝毓坤汤治疗卵巢早衰的疗效观察

Observation of clinical effect of Qiganyukun decoction in treatment of patients with premature ovarian failure

目的探讨启肝毓坤汤治疗卵巢早衰患者的临床疗效。方法选择卵巢早衰患者85例,随机分为两组,其中治疗组46例,对照组39例,对照组用西药雌孕激素序贯疗法,治疗组用启肝毓坤汤,两组均连续治疗3个月,治疗前后采血。对比治疗前后临床症状、雌二醇(E_2)、卵泡刺激素(FSH)、促黄体生成激素(LH)水平的差异。结果治疗组总有效率为89.13%(41/46例),对照组为79.49%(31/39例),两组比较差异有统计学意义(P<0.05)。两组病例经过治疗后,腰酸坠胀症状消失率优于对照组(P<0.05)。两组血清FSH、LH、E_2值治疗前后比较,差异有统计学意义(P<0.05);治疗后血清E_2水平优于对照组(P<0.05),而治疗后两组间FSH、LH的水平无统计学差异(P>0.05)。结论启肝毓坤汤可以有效改善由卵巢早衰引起的激素变化,且能缓解临床症状,临床疗效较好。

Objective To explore the clinical effect of Qiganyukun decoction in treatment of patients with premature ovarian failure（ POF）. Methods A total of 85 patients with POF were selected from the hospital and randomly divided into treatment group（ 46 patients） and control group（ 39 patients）. The patients in control group were treated by western medicine sequential therapy,and the patients in treatment group were treated by Qiganyukun decoction,all the patients were treated for 3 months; blood samples were collected before and after treatment. The clinical symptoms,serum estradiol（ E_2）,follicule-stimulating hormone（ FSH）,leuteinizing hormone（ LH） levels before and after treatment were compared. Results The total effective rates in treatment group and control group were 89. 13%（ 41 /46） and79. 49%（ 31 /39）,respectively,the difference was statistically significant（ P〈0. 05）. After treatment,the disappearance rate of upset impatience in treatment group was faster than that in control group（ P〈0. 05）. There were statistically significant differences in the levels of serum FSH,LH,and E_2 between before and after treatment in the two groups（ P〈0. 05）; after treatment,serum E_2 level in treatment group was better than that in control group（ P〈0. 05）,but there was no statistically significant difference in the levels of serum FSH and LH between the two groups（ P〉0. 05）. Conclusion Qiganyukun decoction can effectively improve the changes of hormone levels and relieve clinical symptoms induced by POF,the clinical effect is good.