糖肾Ⅰ号方联合缬沙坦治疗糖尿病肾病临床观察

Curative Effect of Tangshen Ⅰ Prescription Combined with Valsartan Capsule in Treating Diabetic Nephropathy

目的:观察糖肾Ⅰ号方联合缬沙坦治疗糖尿病肾病的临床疗效。方法:将81例糖尿病肾病患者随机分为对照组和治疗组,在内科常规抗糖尿病治疗的基础上,对照组40例给予缬沙坦胶囊口服,治疗组41例在对照组治疗基础上加用糖肾Ⅰ号方治疗。以15天为1疗程,2组均治疗3疗程,比较2组的临床疗效,并观察治疗前后空腹血糖(FBG)、早餐后2 h血糖(P2h BG)、糖化血红蛋白(Hb A1c)、尿白蛋白排泄率(UAER)、尿微量白蛋白(U-m Alb)、血肌酐(SCr)、尿素氮(BUN)的变化。结果:对照组总有效率为67.5%,治疗组总有效率为82.9%,2组比较,差异有统计意义(P<0.05)。治疗后,2组FBG、P2h BG、Hb A1c水平与治疗前比较无明显变化,差异均无统计学意义(P>0.05)。治疗组UAER、U-m Alb、BUN和对照组UAER、U-m Alb与治疗前比较,差异均有统计学意义(P<0.01,P<0.05);治疗组UAER、BUN、U-m Alb的改善程度均优于对照组(P<0.01,P<0.05)。结论:糖肾Ⅰ号方联合缬沙坦胶囊治疗糖尿病肾病较单用缬沙坦疗效更为确切,可有效缓解糖尿病肾病患者的临床症状,改善肾功能。

Objective： To observe clinical effect of Tangshen I prescription combined with valsartan capsule in treating diabetic nephropathy. Methods：Selected 81 patients with diabetic nephropathy,and divided them into the control group and the treatment group randomly. Based on the routine medical anti-diabetic treatment,40 cases of the control group were treated with valsartan,and 41 cases of the treatment group were treated with Tangshen I prescription based on the treatment of the control group. One course lasted for fifteen days, and the treatment of the two groups both lasted for three courses. Compared the clinical effect of the two groups, and observed changes of fasting blood-glucose（FBG）, postprandial two hours blood glucose（P2h BG）, hemoglobin A1c（Hb A1c）, urinary albumin excretion rate（UAER）, uric micro-albumin（U-m Alb）, serum creatinine（SCr）, blood urea nitrogen（BUN） before and after treatment. Results： The total effective rate was 67.5% and 82.9% in the control group and the treatment group,respectively,the difference being significant（P〈0.05）. After treatment,level of FBG,P2 h BG and Hb A1 c of the two groups has no obvious change（P 〉 0.05 compared with those before treatment）. The differences of levels of UAER, U-m Alb and BUN of the treatment group, and levels of UAER and U-m Alb of the control group before and after treatment were significant（P 〈 0.01,P 〈 0.05）. Improvement degree of UAER, U-m Alb and BUN in the treatment group was better than that of the control group（P 〈 0.01,P 〈 0.05）. Conclusion：Clinical effect of the combination usage of Tangshen I prescription and Valsartan capsule is more accurate than use valsartan capsule alone, for it can relieve the clinical symptom and improve renal function in patients with diabetic nephropathy.