桂枝茯苓胶囊联合宫腔镜下输卵管通液术治疗输卵管阻塞性不孕临床观察

Clinical Observation of Guizhi Fuling Capsule Combined with Hydrotubation under Hysteroscopy in Treating Fallopian Tube Obstructive Infertility

目的:观察桂枝茯苓胶囊联合宫腔镜下输卵管通液术治疗血瘀型输卵管阻塞性不孕的临床疗效。方法:选取本院收治的78例血瘀型输卵管阻塞性不孕患者为研究对象,按照随机数字表法分为观察组和对照组各39例。对照组采用宫腔镜下输卵管通液术治疗,观察组在对照组治疗基础上口服桂枝茯苓胶囊,服药3个月经周期。观察2组治疗前后中医证候总积分的变化,及治疗后输卵管通畅程度和妊娠情况。结果:治疗后,2组中医证候总积分均较治疗前降低(P<0.05),观察组的中医证候总积分较对照组下降更明显(P<0.05)。观察组总有效率94.9%,高于对照组的64.1%(P<0.01)。观察组输卵管通畅率及输卵管总复通率分别为61.4%和80.7%,对照组输卵管通畅率和输卵管总复通率分别为37.5%和58.9%。2组输卵管通畅率及输卵管总复通率比较,差异均有统计学意义(P<0.05)。随访1年,观察组妊娠率为61.5%,高于对照组的35.9%(P<0.05)。结论:桂枝茯苓胶囊联合宫腔镜下输卵管通液术治疗血瘀型输卵管阻塞性不孕,能有效改善患者的临床症状,提高输卵管复通率和妊娠率。

Objective： To observe the clinical effect of Guizhi Fuling capsule combined with hydrotubation under hysteroscopy in treating fallopian tube obstructive infertility. Methods：Selected 78 patients with blood stasis type fallopian tube obstructive infertility in our hospital as study objects, and divided them into the control group and the observation group randomly, 39 cases in each group. The control group was treated with hydrotubation under hysteroscope, the observation group was given Guizhi Fuling capsule based on the treatment of the control group. Medication lasted for three menstrualcycles. Observed change in the total integral of Chinese medicine symptom, tubal patency and pregnancy of the two groups. Results： The total integral of Chinese medicine symptom of the two groups was decreased（P 〈0.05）, and the decline of total integral of Chinese medicine symptom of the observation group was more significant（P 〈0.05 compared with that of the control group）. The total effective rate was 94.9% in the observation group,being higher than the 64.1% in the control group（P〈0.01）. Patency rate and total recanalization rate of tubal in the observation group was 61.4% and 80.7% respectively,and was 37.5% and 58.9% in the control group respectively,the differences being significant（P〈0.05）. After treatment,follow-up for one year,pregnancy rate of the observation group was 61.5%,higher than the 35.9% of the control group（P〈0.05）. Conclusion：Guizhi Fuling capsule combined with hydrotubation under hysteroscopy can effectively improve clinical symptoms of patients, and improve tubal patency rate and total recanalization rate of tubal in treating fallopian tube obstructive infertility.