黄芪注射液联合盐酸拉贝洛尔注射液治疗妊娠高血压综合征临床观察

Clinical Observation of Astragalus Injection Combined with Labetalol Hydrochloride Injection for Pregnancy Induced Hypertension

目的:观察黄芪注射液联合盐酸拉贝洛尔注射液治疗妊娠高血压综合征(PIH)的临床疗效,及其对患者肾功能和妊娠结局的影响。方法:按随机数字表法将78例PIH患者分为对照组和研究组各39例。对照组给予盐酸拉贝洛尔注射液治疗,研究组在对照组用药基础上加用黄芪注射液。比较2组临床疗效,观察2组治疗前后肾功能指标的变化,记录2组妊娠结局。结果:研究组总有效率94.87%,对照组79.49%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组α1-微球蛋白(α1-MG)、尿素氮(BUN)、尿肌酐(UCr)及尿酸(UA)水平均较治疗前降低(P<0.01),研究组α1-MG、BUN、UCr及UA水平均低于对照组(P<0.01)。治疗后研究组胎心异常发生率和新生儿窒息发生率均低于对照组(P<0.05)。结论:黄芪注射液联合盐酸拉贝洛尔注射液治疗PIH,能提高患者的临床疗效,改善肾功能和妊娠结局。

Objective： To observe the clinical effect of astragalus injection combined with labetalol hydrochloride injection for pregnancy induced hypertension（PIH） and the effect on renal function and pregnancy outcome of patients. Methods：Divided 78 cases of PIH patients into the control group and the study group randomly, 39 cases in each group. Both groups were given labetalol hydrochloride injection, while the study group was additionally treated with astragalus injection. Compared the clinical effect and changes of renal function indexes in both groups before and after treatment. Results：The total effective rate was 94.87% in the study group and 79.49% in the control group,the significant difference being found in the comparison between two groups（P〈0.05）. After treatment,levels of α1-Microglobulin（α1-MG）,blood urea nitrogen（BUN）,urinary creatinine（UCr） and uric acid（UA） were declined（P〈0.01）. Levels of α1-MG,BUN,UCr and UA in the study group were all lower than those in the control group（P〈0.01）. The incidence of abnormal fetal heart rate and the incidence of neonatal asphyxia in the study group were lower than those in the control group（P〈0.05）. Conclusion：Astragalus injection combined with labetalol hydrochloride injection for PIH can enhance clinical effect,and it can also improve pregnancy outcome.