银翘芩百汤联合阿奇霉素治疗小儿支原体肺炎临床观察

Observation of Yinqiao Qinbai Tang Combined with Azithromycin for Children Mycoplasma Pneumonia

目的:观察银翘芩百汤联合阿奇霉素治疗小儿支原体肺炎风热闭肺证的临床疗效。方法:选取80例支原体肺炎风热闭肺证患儿,按照随机数字表法分为对照组与治疗组各40例。对照组给予阿奇霉素颗粒治疗,治疗组在对照组用药基础上加用银翘芩百汤。观察2组治疗前后白细胞计数、C-反应蛋白和血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平的变化,比较2组治疗前后的中医证候积分及临床疗效,观察2组治疗期间的不良反应发生情况。结果:治疗后,2组白细胞计数、C-反应蛋白和血清IL-6、IL-10、TNF-α水平均较治疗前降低(P<0.05);治疗组以上5项指标水平均低于对照组(P<0.05)。治疗后,2组中医证候积分均较治疗前降低(P<0.01);治疗组的中医证候积分低于对照组(P<0.01)。治疗组总有效率97.5%,对照组总有效率80.0%。2组比较,差异有统计学意义(P<0.05)。结论:银翘芩百汤联合阿奇霉素治疗小儿支原体肺炎风热闭肺证,能有效控制炎症反应,改善患儿的临床症状,提高临床疗效,且用药安全。

Objective： To observe the clinical effect of Yinqiao Qinbai tang combined with azithromycin for children mycoplasma pneumonia with wind and heat blocking the lung syndrome. Methods： Selected 80 mycoplasma pneumonia patients with wind and heat blocking the lung syndrome,and divided them into the control group and the treatment group randomly,40 cases in each. The control group was given azithromycin granules,and the treatment group was given Yinqiao Qinbai tang based on the treatment of the control group. Observed change of levels of leukocyte count, C-reactive Protein, serum interleukin-6（IL-6）,interleukin-10（IL-10）, tumor necrosis factor-α（TNF-α） of the two groups, compared integral of Chinese medicine symptom and clinical effect of the two groups before and after treatment, and observed adverse reactions of the two groups during medication.Results：After treatment,levels of leukocyte count,C-reactive Protein,serum IL-6,IL-10 and TNF-αof the two groups were lower than those before treatment（P〈0.05）. Levels of the five indexes above in the treatment group were all lower than those in the control group（P〈0.05）. After treatment,integral of Chinese medicine symptom of the two groups was lower than that before treatment（P〈0.01）. Integral of Chinese medicine symptom of the treatment group was lower than that of the control group（P 〈0.01）. The total effective rate was 97.5% in the treatment group, and was 80.0% in the control group, the difference being significant（P 〈0.05）.Conclusion： Yinqiao Qinbai tang combined with azithromycin can effectively control the inflammatory response, improve clinical symptoms in patients and improve clinical effect in treating children mycoplasma pneumonia with wind and heat blocking the lung syndrome,which is safe.