平喘汤联合GINA阶梯方案治疗小儿支气管哮喘缓解期临床观察

Observation of Pingchuan Tang Combined with GINA Ladder Program for Children Bronchial Asthma of Remission Stage

目的:观察平喘汤联合哮喘全球防治创议(GINA)阶梯方案对肺脾两虚支气管哮喘缓解期患儿血清超敏C反应蛋白(hs-CRP)、免疫球蛋白E(lg E)、肺功能、哮喘控制及生活质量的影响。方法:将110例肺脾两虚型支气管哮喘缓解期患儿随机分为观察组和对照组各55例。对照组采用GINA阶梯方案治疗,观察组在对照组用药基础上给予平喘汤治疗,2组均用药3月。观察2组治疗前后血清hs-CRP、lg E水平及肺功能、生活质量的变化,治疗后比较2组哮喘的控制情况。结果:治疗后,2组血清hs-CRP及lg E水平均较治疗前降低(P<0.05),FEV_1、FEV_1/FVC值均较治疗前升高(P<0.05);观察组的血清hs-CRP及lg E水平均低于对照组(P<0.05),FEV_1、FEV_1/FVC值均高于对照组(P<0.05)。治疗后观察组哮喘总控制率90.9%,对照组哮喘总控制率74.5%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组症状维度评分、活动受限维度评分、情感维度评分及总评分均较治疗前升高(P<0.05);观察组的各项评分均高于对照组(P<0.05)。结论:平喘汤联合GINA阶梯方案治疗肺脾两虚型支气管哮喘缓解期,能有效降低患儿的血清hs-CRP及lg E水平,改善肺功能,提高哮喘控制率和生活质量。

Objective ： To observe the effect of Pingchuan tang combined with Global Initiative for Asthma（GINA）ladder program on relieving serum high-sensitivity C-reactive protein（hs-CRP）, immunoglobulin E（lg E）, pulmonary function, asthma control and quality of life. Methods： Selected 110 children with bronchial asthma of remission stage,and divided them into the observation group and the control group with 55 cases in each randomly. The control group was treated with GINA ladder program, and the observation group was given Pingchuan tang based on the treatment of the control group. Medication both lasted for three months. Observed change of serum hs-CRP, lg E level, pulmonary function and quality of life of the two groups before and after treatment, and compared the asthma control of the two groups after treatment. Results： After treatment, serum hs-CRP and lg E levels of the two groups were lower than those before treatment（P 〈 0.05）, FEV1（forced expiratory volume in one second）and score of FEV1/FVC（forced expiratory volume in one second/forced vital capacity） were higher than those before treatment（P〈0.05）. Serum hs-CRP and lg E levels of the observation group were both lower than those of the control group（P〈0.05）, FEV1 and score of FEV1/FVC of the observation group both were higher than those of the control group（P〈0.05）. After treatment,asthma general control rate was 90.9% and 74.5% in the observation group and the control group respectively,the difference being significant（P〈0.05）. After treatment,dimension scores of symptom,activity restriction and emotion,and the total scores were all higher than those before treatment（P〈0.05）,and the scores of the observation group were higher than those of the control group（P〈0.05）. Conclusion： Pingchuan tang combined with GINA ladder program can effectively decrease hs-CRP and lg E levels of patients,improve pulmonary function,asthma control rate and quality of life.