摘要
急性淋巴细胞白血病是一种高度异质性疾病。甲氨蝶呤(MTX)是治疗儿童及成人急性淋巴细胞白血病的常用化疗药物,大剂量甲氨蝶呤逐渐代替头颅放疗成为预防中枢神经系统复发及治疗的主要措施,大大提高了患者的无事件生存率和总生存率。大剂量MTX的不良反应主要有肝、肾功能损害,骨髓抑制,口腔黏膜炎等,亚叶酸钙作为大剂量MTX特异性解毒药物可以对抗其细胞毒效应。
Acute lymphoblastic leukemia （ALL） is methotrexate （MTX） is the common chemotherapy in treating place of cranial radiotherapy and becomes the main measure nervous system relapse. That greatly improves the event- free a highly heterogeneous disease. High- dose children and adults ALL. It gradually takes the of the prophylaxis and treatment in the central survival （EFS） and overall survival （OS） of patients. The main adverse reactions of high-dose MTX are liver and kidney damage, bone marrow suppression, oral mucositis, and so on. Leucovorin is the high-dose MTX specific antidote which can reduce cytotoxic effects of high-dose MTX.
作者
陈丽娜
华建媛
郑积富
石庆之
CHEN Li-na HUA Jian-yuan ZHENG Ji-fu SHI Qing-zhi(Department of Hematology, the Second Affiliated Hospital of Nanchang University, Nanchang JIANGX1 330006, China Key Laboratory of Experimental Hematology, Nanchang JIANGXI 330006, China School of Medicine, Graduate School of Nanchang University, Nanchang JIANGXI 330006, China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2017年第1期7-10,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
江西省卫生计生委科技计划(20155331)
江西省科技支撑计划项目(20151BBG70169)
关键词
甲氨蝶呤
白血病
淋巴细胞
急性
亚叶酸钙
药物毒性
methotrexate
leukemia, lymphoblastic, acute
calcium folinate
drug toxicity
