人脐带间充质干细胞治疗重度烧伤后ALI的展望

Advance on human umbilical cord mesenchymal stem cells for treatment of ALI in severe burns

重度烧伤常伴发多器官损伤，急性肺损伤（ALI）是最常见的并发症之一，且常在重度烧伤早期发生，如不及时处理，则进展为急性呼吸窘迫综合征（ARDS），严重威胁患者的生命。目前，对于重症烧伤后ALI的治疗仍停留在液体复苏、对原发部位处理、通气支持及抗感染等方面。近年研究发现，人脐带间充质干细胞（hUCMSCs）对多种原因引起的ALI有较好的疗效，但对重度烧伤引起ALI的疗效鲜有报道。通过回顾有关干细胞治疗ALI的机制研究，展望hUCMSCs对重度烧伤后ALI的治疗前景，为临床治疗提供新的思路。

Severe burn is often accompanied by multiple organ damage. Acute lung injury （ALI） is one of the most common complications, and often occurs in the early stage of severe bums. If it is not treated in time, it will progress to acute respiratory distress syndrome （ARDS）, which will be a serious threat to the lives of patients. At present, the treatment of ALI in patients with severe bum is still remained in some common ways, such as the liquid resuscitation, the primary wound treatment, ventilation support, and anti-infection. In recently, human umbilical cord mesenchymal stem cells （hUCMSCs） have been found having some good effects on ALI caused by various causes, but few reports on the efficacy of ALl caused by severe burns were reported. By reviewing the mechanism of stem cell therapy for ALI, therapeutic potential of hUCMSCs in the treatment of severe bums with ALI and a new approach for clinical treatment was provided.