发病间隔时间和内分泌疗法对双侧乳腺癌妇女生存状况的影响

Effects of time interval and the endocrine therapy on the survival conditions in women with bilateral breast cancer

目的探讨发病间隔时间和内分泌治疗对于双侧乳腺癌妇女生存状况的影响。方法回顾性分析64例双侧乳腺癌患者的病例资料,根据不同发病间隔时间(<6个月、6个月~2年、>2年)分别A组、B组和C组;根据第一原发癌术后是否接受内分泌治疗情况分为观察组和对照组。比较各组患者之间的生存时间以及无疾病生存期,并对患者治疗前后生活质量情况进行对比分析。结果 C组患者生存时间以及无疾病生存期情况明显优于其余两组,差异具有统计学意义(P均<0.05);观察组患者的生存时间以及无疾病生存期明显高于对照组患者,差异具有统计学意义(P均<0.05);两组患者的总生活质量评分较治疗前有所升高,且观察组升高较明显,差异均有统计学意义(t分别=6.81、5.91、6.07,P均<0.05)。结论双侧乳腺癌两癌发生的时间间隔的延长、手术治疗后给予内分泌治疗能够有效地改善患者的生存状况,延长患者的生存期,提高患者的生活质量。

Objective To study the effects of time interval and the endocrine therapy on the survival conditions in women with bilateral breast cancer. Methods Clinical datas of 64 patients with bilateral breast cancer were retrospectively analyzed. According to the different paroxysm time,the patients were divided into group A（less than 6 months）,group B（6months to 2 years） and group C（above 2 years）.According to whether received postoperative endocrine therapy after the first primary lung cancer or not,the patients were divided into observation group and control group. The survival time and disease free survival were compared. At the same time,the qualities of life before and after treatment were analyzed. Results The survival time and disease free survival in group C were significantly longer than the group A and group B（P〈0.05）.The survival time and disease free survival in observation group were significantly better than those in control group（P〈0.05）. The scores of quality of life in two groups were higher than before treatment,and those in the observation group were increased obviously（t=6.81,5.91,6.07,P〈0.05）. Conclusion The longer time interval and endocrine therapy after surgery can effectively improve the living condition of patients,prolong the time of survival and improve the quality of life.