自拟中药组方对功能性消化不良患者胃舒张与胃排空功能的影响

Effect of self-made traditional Chinese medicine compound for the stomach diastolic and gastric emptying function of patients with functional dyspepsia

目的探讨自拟中药组方对功能性消化不良患者胃舒张与胃排空功能的影响。方法将2014年4月~2015年6月于沧州市人民医院就诊的功能性消化不良患者200例随机分为观察组与对照组,各100例。其中对照组服用莫沙必利,观察组则服用自拟中药组方。比较两组患者胃舒张、胃排空功能以及治疗效果、不良反应的差异。结果观察组临床总有效率为93.0%,与对照组(73.0%)比较,差异有统计学意义(P<0.05)。治疗后两组患者胃底气体评分,10、30、60 min的近端胃容积,症状积分(饱胀感计分,胃灼热感计分,恶心、嗳气、反酸计分,总分)均较治疗前明显降低(P<0.05),胃排空率及血浆中胃动素浓度较治疗前明显升高(P<0.05)。两组治疗后胃底气体评分,10、30、60 min的近端胃容积,以及血浆中胃动素浓度比较,差异无统计学意义(P>0.05)。观察组治疗后胃排空率明显高于对照组(P<0.05),症状积分(饱胀感计分,胃灼热感计分,恶心、嗳气、反酸计分,总分)明显低于对照组(P<0.05)。两组均未出现明显不良反应。结论自拟中药组方治疗功能性消化不良效果显著,副作用小,值得临床借鉴。

Objective To investigate the effect of self-made traditional Chinese medicine compound for the stomach diastolic and gastric emptying function of patients with functional dyspepsia. Methods Two hundred cases of patients with functional dyspepsia admitted to Cangzhou People＇s Hospital from April 2014 to June 2015 were randomly divided into observation group and control group, with 100 cases in each group. The control group received Mosapride, while the observation group was given self-made traditional Chinese medicine compound. The differences of stomach diastolic and gastric emptying function, the clinical effect and side effect between two groups were compared. Results The total effective rate of observation group was 93.0%, which had significant difference compared with that of control group（73.0%）（P〈0.05）. After treatment, the scores of gas in gastric fundus, proximal stomach volume at 10, 30, 60 min, the symptom scores（satiety score, heartburn score, nausea-belching-acid regurgitation score, total score） of the two groups were significantly lower than those before treatment（P〈0.05）, and the rate of gastric emptying, the plasma concentration of motilin of two groups were significantly higher than those before treatment（P〈0.05）. The scores of gas in gastric fundus, proximal stomach volume at 10, 30, 60 min, and the plasma concentration of motilin between the two groups after treatment had no significant differences（P〉0.05）. The rate of gastric emptying in observation group after treatment was much higher than that in control group（P〈0.05）, the symptom scores（satiety score, heartburn score, nauseabelching-acid regurgitation score, total score） in observation group after treatment were significantly lower than those of control group（P〈0.05）. The adverse reactions were not appeared in both groups. Conclusion Self-made traditional Chinese medicine compound in the treatment of functional dyspepsia has good clinical effects and few side effects, which is worthy of clinical reference.