栀子厚朴汤加减联合生石膏治疗焦虑症的临床效果

Clinical effect of Modified Fructus Gardeniae and Cortex Magnoliae Officinalis Decoction combined with gypsum in the treatment of anxiety disorder

目的探讨栀子厚朴汤加减联合生石膏治疗焦虑症的临床效果。方法选择2013年1月~2015年6月辽宁中医药大学附属第二医院收治的66例焦虑症患者,按照随机数字表法将其分为治疗组和对照组,各33例。治疗组给予栀子厚朴汤加减联合生石膏治疗,对照组给予抗焦虑药艾司唑仑片治疗。观察比较两组汉密尔顿焦虑量表(HAMA)疗效、评分,以及中医证候疗效、中医证候主证积分情况。结果治疗组HAMA疗效总有效率为97.0%,对照组为84.8%,差异有统计学意义(P<0.05)。两组治疗后HAMA总评分、精神性焦虑因子评分、躯体性焦虑因子评分均较治疗前明显降低,差异有统计学意义(P<0.05)。治疗组治疗后HAMA总评分明显低于对照组(P<0.05),两组治疗后精神性焦虑因子评分、躯体性焦虑因子评分比较,差异无统计学意义(P>0.05)。治疗组中医证候疗效总有效率为90.9%,对照组为51.5%,差异有高度统计学意义(P<0.01)。两组治疗后暴躁易怒、失眠心悸评分均较治疗前明显降低(P<0.05),且治疗组治疗后暴躁易怒、失眠心悸评分均明显低于对照组,差异有统计学意义(P<0.05)。结论栀子厚朴汤和生石膏治疗焦虑症可以有效缓解患者的不良情绪,提高患者生活质量。

Objective To investigate the clinical effect of Modified Fructus Gardeniae and Cortex Magnoliae Officinalis Decoction combined with gypsum in the treatment of anxiety disorder. Methods Sixty-six patients with anxiety disorder admitted to the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2013 to June 2015 were selected and divided into treatment group and control group according to the random number table method, with 33 cases in each group. The treatment group was treated with Modified Fructus Gardeniae and Cortex Magnoliae Officinalis Decoction combined with gypsum treatment, the control group was treated with anti-anxiety medicine Estazolam Tablets. The curative effect and scores of Hamilton anxiety scale（HAMA）, the efficacy of traditional Chinese medicine syndrome, and the scores of main traditional Chinese medicine syndromes in the two groups were observed and compared. Results The total effective rate of HAMA efficacy in the treatment group was 97.0%,which of control group was 84.8%, the difference was statistically significant（P〈0.05）. The total scores of HAMA and mental anxiety factor scores, somatic anxiety factor scores of the two groups after treatment were all lower than those before treatment, the differences were statistically significant（P〈0.05）. The total score of HAMA in the treatment group after treatment was significantly lower than that of control group（P〈0.05）, while there were no statistically significant differences of mental anxiety factor scores and somatic anxiety factor scores between the two groups after treatment（P〈0.05）. The total effective rate of TCM syndrome in the treatment group was 90.9%, which of control group was 51.5%, the difference was highly statistically significant（P〈0.01）. The scores of irritability and insomnia in the two groups after treatment were all lower than those before treatment（P〈0.05）, and the scores of irritability and insomnia in the treatment group after treatment were all lower than those of control group, the differences were statistically significant（P〈0.05）. Conclusion Fructus Gardeniae and Cortex Magnoliae Officinalis Decoction combined with gypsum in the treatment of anxiety disorder can effectively alleviate the negative emotions of patients, improve the quality of life.