冠心病患者经皮冠状动脉介入术治疗后血浆IL-12、MCP-1的水平变化

Plasma IL-12 and MCP-1 in Patients with Coronary Artery after Percutaneous Coronary Intervention

【目的】探讨冠心病（CHD）患者经皮冠状动脉介入术（PCI）治疗后血浆IL-12、MCP-1水平变化及其与患者短期预后的相关性。【方法】选择2013年1月至2015年12月本院收治的268例CHD患者的临床资料将其分为观察组，另外选取同时期在本院行冠状动脉造影术显示冠脉正常的健康志愿者50例作为对照组，比较两组的血浆IL－12、MCP－1水平，观察CHD患者不良心血管事件的发生情况，并分析IL-12、MCP-1水平与不良心血管事件的相关性。【结果】术前，观察组血浆IL-12、MCP-1显著高于对照组，两组比较差异均具有统计学意义（均P〈0．05）；行PCI术后，观察组血浆IL-12、MCP-1水平显著低于术前，差异均具有统计学意义（均P〈0．05），而对照组在造影术前后血浆IL-12、MCP-1水平比较，差异均无统计学意义（均P〉0．05）。血浆IL-12、MCP-1水平与主要不良心血管事件发生具有显著正相关性（均P〈0．05）。【结论】CHD患者经PCI术治疗后血浆IL-12、MCP-1水平显著降低，其与CHD患者的短期不良预后具有一定的相关性。

[ Objective]To explore the changes of plasma IL-12 and MCP-1 for patients with coronary artery after percutaneous coronary intervention, and the correlation with short-term prognosis. [ Methods ] Clinical data of 268 patients with CHD from January 2013 to December 2015 in our hospital were set as the observation group, and 50 healthy volunteers underwent coronary angiography with normal coronary arteries were selected in the same period of time in our hospital as the control group. The plasma levels of IL-12 and MCP-1 were compared between the two groups. The ineidenee of adverse eardiovascular events in CHD patients was observed, and the correlation between IL-12 and MCP-1 levels and adverse cardiovascular events were analyzed. [ Results] Before surgery, plasma IL-12, MCP-1 levels in observation group were significantly higher than those of the control group, the difference was significant （ mean P 〈 0.05） ; After surgical treatment of PCI, a significant decrease in the above levels were found in the observation group, the difference was significant （ mean P 〈 0.05） , while there was no significant difference before and after angiography in the control group, the difference was not statistically significant（ mean P 〉 0.05 ） ; Plasma IL-12 and MCP-1 levels were positively correlated with major adverse eardiovascular events （mean P 〈 0.05 ）. [ Conclusion] Plasma IL-12 and MCP-1 levels were significantly lower in patients with CHD after PCI; this could be correlative with the short term adverse prognosis of patients with CHD.