明胶/海藻酸钠复合微球的研究

Research on gelatin/sodium alginate complex microsphere material

以明胶和海藻酸钠(SA)为原料制备了复合微球,并对微球性能进行了研究。结果表明:微球干燥速率先快后慢,随着温度的升高,微球干燥较快且容易达到平衡;混合溶液滴入氯化钙溶液中会迅速成球,0.5h内凝胶化速率变化较大,随后速率变化减小,2h后凝胶化速率几乎保持不变;微球载药量越高,释放速率越快;在中性环境中,微球释放药物的速率很快,迅速达到平衡;在酸性环境中,微球的释药速率缓慢。

Gelatin（GT）and sodium alginate（SA）were used for the preparation of composite microspheres.And its properties were studied.Studies shown：the drying rate of microspheres was slow after the first fast.And as the temperature rised,the dryness of microspheres was fast and easy to reach equilibrium.When mixed solution were dropped into calcium chloride solution,droplets rapidly became microspheres.In 0.5h,the rate of gelation had a large changes,then the change slowed down.After 2hthe rate of gelation almost unchanged.When the drug loading of microspheres was higher,the release rate was faster.In neutral solution,the rate of drug release was faster,and it reached equilibrium quickly.In acidic environment,drug release rate of microspheres was slow.The research of microspheres would provide an important basis for its application in clinical.