摘要
细胞自噬指细胞利用溶酶体降解细胞质中错误折叠的蛋白质及受损细胞器等,重新利用降解物质及胞内有害物质的过程,以维持细胞内环境稳定。正常状态下细胞的自噬维持在低水平,当细胞处在不利因素条件下,自噬也会被激活应对不利因素。自噬在肿瘤发生、发展、转移、复发、药物抵抗等方面有着重要作用,但自噬在这些方面的详细机制仍不清楚。我们在文中对宫颈癌细胞中自噬相关基因的表达情况进行了阐述,自噬治疗在宫颈癌中具有重要的应用前景。
Cell autophagy refers to use lysosomes to degrade the misfolded proteins and the damaged organelles in the cytoplasm.This process can reuse the intracellular degradation substances in order to maintain stable environment in the cell.Normal cells maintain at a low level of autophagy.When a cell is under the condition of unfavorable factors,its autophagy can be activated against unfavorable factors.Autophagy plays an important role in cancer occurrence,development,metastasis,recurrence and drug resistance,but the detailed mechanism of autophagy in these areas is still unclear.In this paper,the autophagy-related genes in cervical cancer cells and their application in cervical cancer treatment are reviewed.
出处
《解剖学报》
CAS
CSCD
北大核心
2017年第1期111-114,共4页
Acta Anatomica Sinica
