中西医结合一体化治疗阿拉伯国家慢性肾脏病临床研究

Effect of the integration of traditional Chinese medicine and western medicine treatment on patients with chronic kidney disease from the Arab countries

目的探讨中西医结合一体化治疗阿拉伯国家慢性肾脏病患者的临床疗效。方法选取2012年12月至2015年12月在我院住院治疗的阿拉伯国家慢性肾脏病患者378例,按照随机数表法分为对照组和观察组,每组189例。对照组患者采用西医对症与辨证口服中药治疗,观察组采用西医对症与辨证口服中药治疗的基础上,加用口服脉康合剂与双肾区外敷、熏蒸、药浴、灸疗等一系列中医外治方法,治疗6个月。比较两组患者的临床症状积分、肾功能相关指标、生存质量和临床疗效。结果观察组患者的倦怠乏力、腰酸腿软、食少纳呆、畏寒肢冷、水肿[(1.56±0.32)分、(1.87±0.83)分、(1.72±0.74)分、(1.21±0.73)分、(1.34±0.93)分]等临床症状积分明显低于对照组的(2.13±0.72)分、(2.52±0.81)分、(2.37±0.69)分、(1.89±0.78)分、(3.05±0.98)分,差异均有统计学意义(P<0.05);观察组患者的24 h尿蛋白定量[(0.81±0.62)g/m L]、尿素氮[(8.16±1.87)mmol/L]和尿酸[(403.29±81.25)μmol/L]明显低于对照组的(1.24±0.72)g/m L、(9.57±2.14)mmol/L、(452.19±83.74)μmol/L,肾小球滤过率[(56.71±13.65)m L/(min·1.73 m2)]明显高于对照组的(49.37±10.21)m L/(min·1.73 m2),差异均有统计学意义(P<0.05);观察组患者的情绪功能、认知功能、角色功能、躯体功能和社会功能评分[(69.37±11.04)分、(70.83±12.27)分、(74.11±11.83)分、(75.21±11.33)分、(78.77±12.29)分]高于对照组的(63.26±11.23)分、(65.63±12.17)分、(67.56±11.57)分、(68.69±11.56)分、(72.17±13.52)分,差异均有统计学意义(P<0.05);观察组的治疗总有效率为80.95%,明显高于对照组的67.72%,差异有统计学意义(P<0.05)。结论中西医结合一体化治疗阿拉伯国家慢性肾脏病可改善患者的临床症状、改善肾功能,提高生活质量,具有较好的临床疗效。

Objective To study the integration of traditional Chinese medicine and western medicine treatment on patients with chronic kidney disease from the Arab countries. Methods A total of 378 patients Chronic Kidney Disease from Arab countries in our hospital from December, 2012 to December, 2015 were divided into the control group（189 cases） and observation group（189 cases） according to random number table method. The control group was given symptomatic treatment with western medicine and traditional Chinese medicine syndrome differentiation treatments, and the observation group was given Mai kang oral mixture and double renal area external application treatment, fumigation,medicated bath, moxibustion and a series of Chinese medicine external treatment methods on the basis of the control group. The patients were all treated for 6 months. The clinical symptoms integral, related parameters of renal function and survival quality evaluation, clinical curative effect of two groups were compared between the two groups. Results The scores of languid, sore waist with weak leg, poor appetite, fear of cold with cold limbs, edema in observation group after treatment were（1.56 ± 0.32）,（1.87 ± 0.83）,（1.72 ± 0.74）,（1.21 ± 0.73）,（1.34 ± 0.93）, which were significantly lower than those in the control group of（2.13±0.72）,（2.52±0.81）,（2.37±0.69）,（1.89±0.78）,（3.05±0.98）, and the differences between two groups were statistically significant（P0.05）. The 24-hour urine protein quantity, blood urea nitrogen and uric acid in observation group were（0.81±0.62） g/m L,（8.16±1.87） mmol/L,（403.29±81.25） μmol/L, which were significantly lower than those in the control group of（1.24±0.72） g/m L,（9.57±2.14） mmol/L and（452.19±83.74） μmol/L, and the glomerular filtration rate was significantly higher than that in the control group,（56.71 ± 13.65） m L/（min·1.73 m2） vs（49.37 ±10.21） m L/（min·1.73 m2）（P0.05）. The quality of life scores of emotional function, cognitive function, role function,physical function in the observation group were（69.37 ± 11.04）,（70.83 ± 12.27）,（74.11 ± 11.83）,（75.21 ± 11.33）, which were significantly higher than those in the control group of（63.26±11.23）,（65.63±12.17）,（67.56±11.57）,（68.69±11.56）,and the differences were statistically significant（P0.05）. The total effective rate in observation group was 80.95%, significantly higher than 67.72% of the control group, P0.05. Conclusion The integration of traditional Chinese medicine and western medicine treatment on patients with chronic kidney disease from Arab countries can help to improve clinical symptoms, promote renal function, and enhance the quality of life, and results in better clinical curative effect.