Wnt/β-catenin信号通路与肾脏疾病

wnt/β-catenin signaling pathway and kidney disease

wnt信号通路的异常调节已经在许多疾病中被研究,包括肾脏疾病。wnt信号通路传导主要分为两类:经典wnt信号通路、非经典wnt信号通路。其中对经典wnt信号通路,即wnt/β-catenin的研究最为深入。wnt/β-catenin信号通路在肾脏的产生、损伤修复及其他肾脏疾病中有着重要的作用。但是wnt/β-catenin如何影响相关肾脏疾病的机制仍不是非常明确。本文简单总结了近来wnt/β-catenin信号通路与肾脏疾病的相关进展。

Dysregulation of Wnt pathway has been studied in many diseases, including renal disease. wnt pathway cascade has two distinct branches： the canonical Wnt pathway and non-canonical pathway. The research of wnt/β-catenin, the canonical wnt pathway, is the most thorough. wnt/β-catenin is a developmental signaling pathway that has importance role in regulating nephron formation during embryogenesis, injury repair and other kidney diseases. However, how the wnt/β-catenin work in renal disease is still unclear. This review summarizes the recent progress toward understanding of wnt/β-catenin signaling pathway and kidney disease.