电针治疗对大鼠坐骨神经损伤功能修复的作用

Effect of electroacupuncture on functional recovery of injured sciatic nerves in rats

目的:探讨电针治疗(EA)对大鼠坐骨神经损伤功能修复的作用机制。方法:40只大鼠随机分为模型组(Injury组)、损伤后EA治疗组(Injury+EA组),建立大鼠坐骨神经损伤模型,损伤模型成功后给予电针治疗。通过检测治疗前后展爪反射,趾间距,腓肠肌湿重的恢复率,以及脊髓诱发电位、运动诱发电位变化,观察电针治疗对大鼠坐骨神经损伤修复的作用机制。结果:大鼠坐骨神经损伤后给予电针治疗,能显著促进大鼠坐骨神经损伤后受损运动和感觉功能的恢复,降低肌肉萎缩。与Injury组比较,Injury+EA组展爪反射的恢复时间显著缩短(P<0.01),各组大鼠1~5趾趾间距显著增加(P<0.01),腓肠肌湿重的恢复率显著提高(P<0.01),感觉诱发电位波形恢复显著(P<0.01),消失的波形有部分恢复(95%),显著高于Injury组(86%)(P<0.05)。结论:电针治疗能促进大鼠坐骨神经损伤后的功能修复,延迟肌肉萎缩。

Objective To investigate the functional repair of electroacupuncture（EA） on injured sciatic nerves in rats. Methods Forty rats were randomly divided into Injury group and Injury ＋ EA group. After the model of injured sciatic nerves was established in 40 rats, Injury＋EA group was treated with EA. The function repair of EA on injured sciatic nerves was observed by the examination of somatosensory evoked potential（SEP）, motor evoked potential（MEP）, gastrocnemius wet weight,expanding paw reflection and the distance between the first and fifth toes（TS）. Results EA for injured sciatic nerves in rats significantly promotes the recovery of the motor and sensory functions and reduces the muscle atrophy. Compared with Injury group, Injury＋EA group showed a shortened recovery time of expanding paw reflection, increased TS, improved recovery rate of gastrocnemius wet weight, and obvious SEP recovery（P〈0.01 for all）. And the recovery of MEP in Injury＋EA group and in Injury group were 95% and 86%, respectively（P〈0.05）. Conclusion EA promotes the repair of injured sciatic nerves and delay gastrocnemius atrophy in rats.