硫辛酸对慢性酒精中毒性周围神经病的临床疗效

The clinical effect of sulfur acid on chronic alcoholic peripheral neuropathy

目的观察硫辛酸对慢性酒精性周围神经病(CAPN)的临床疗效。方法 48例CAPN患者采用数字法随机分为治疗组和对照组,每组24例,治疗组给予硫辛酸静脉滴注,0.6 g/d;对照组给予甲钴胺注射液避光静脉滴注500μg/d,两组均连用3 w,比较治疗3 w后患者临床症状改善情况,以及腓总神经、正中神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV)的变化。结果治疗组总有效率为64.6%,临床疗效明显优于对照组(41.7%),差异有统计学意义(P<0.05);治疗组腓总神经、正中神经的运动传导速度(MCV)和感觉传导(SCV)与对照组比较明显增加,差异有统计学意义(P<0.05)。结论硫辛酸能改善CAPN患者的临床症状,明显提高神经传导速度(NCV),值得临床应用及研究。

Objective To observe the clinical effect of sulfur acid on chronic alcoholic peripheral neuropathy.Method 48 cases of CAPN patients were recruited from Department of Neurology,Baoji city by randomly divided into treatment group and control group,24 cases in each group; the treatment group was given intravenous injection of lipoic acid0. 6g / d; the control group was given intravenous infusion of Mecobalamin injection light 500 ug / d. After 3 weeks treatment,compared the two groups of clinical symptoms,motor nerve conduction velocity（ MCV） and sensory nerve conduction velocity（ SCV） of the common peroneal nerve and median nerve. Result The total efficiency of treatment group was 64. 6%,the clinical curative effect was significantly better than the control group（ 41. 7%）,the difference was statistically significant（ P〈0. 05）; Motor conduction velocity of common peroneal nerve,median nerve（ MCV） and sensory conduction（ SCV） in treatment group increased significantly compared with the control group,the difference was statistically significant（ P〈0. 05）. Conclusion Sulfur acid can improve the clinical symptoms of CAPN patients,significantly improve the nerve conduction velocity（ NCV）,it is worthy of clinical application and research in large scale.