原发性高血压患者颈动脉粥样硬化与中性粒细胞/淋巴细胞比值和血清总胆红素水平的关系

Relationship between serum total bilirubin level and neutrophil/lymphocyte ratio and carotid atherosclerosis in patients with essential hypertension

目的探讨原发性高血压(EH)患者颈动脉粥样硬化与中性粒细胞/淋巴细胞比值(NLR)和血清总胆红素(STB)水平之间的关系。方法 EH患者571例,根据颈动脉超声结果,按颈动脉粥样硬化不同分为内膜光滑组(95例)、内膜增厚组(118例)、散在斑块组(177例)、多发斑块组(79例)、狭窄斑块组(102例),同时检测五组患者的血常规(计算NLR)和STB水平,并进行统计学分析。结果单因素分析显示,各组年龄、性别、体重指数(BMI)、糖尿病(DM)、糖化血红蛋白(Hb A1c)、NLR、STB、血红蛋白(HGB)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)比较均有统计学差异(P<0.05)。多分类Logistic回归分析显示,年龄、BMI、LDL-C、NLR和STB为EH患者颈动脉粥样硬化的独立危险因素。结论 EH患者颈动脉粥样硬化与NLR和STB水平关系密切。

Objective To study the relationship between serum total bilirubin （STB） level and neutrophil/lymphocyte ratio （NLR） and carotid atherosclerosis in patients with essential hypertension （EH）. Methods Five hundred and seventy-one patients with EH detected by carotid uhrasonography were divided into smooth intima （ n = 95 ）, thickened intima （ n = 118 ）, a few plaques （ n = 177 ）, multiple atheroscle- rosis plaques（ n = 79）and stenotic plaques（ n= 102）groups. Their blood routine and STB levels were detected and NLR were calculated. Resuits The ratio of diabetes, males, age, BMI, NLR , STB, TC, LDL-C, HbA1 c and HG.B of patients in the five groups had significant differences （ P = 0.011,0.018,0.000,0.001,0.005,0.005,0. 003,0. 004,0.015,0. 000, respectively）. Multinomial logistic regression a- nalysis showed that age, BMI, LDL-C, NLR and STB were the independent risk factors of carotid atherosclerosis with EH. Conclusions STB level and NLR are correlated with carotid atherosclerosis in patients with EH.