摘要
目的探讨原发性高血压(EH)患者颈动脉粥样硬化与中性粒细胞/淋巴细胞比值(NLR)和血清总胆红素(STB)水平之间的关系。方法 EH患者571例,根据颈动脉超声结果,按颈动脉粥样硬化不同分为内膜光滑组(95例)、内膜增厚组(118例)、散在斑块组(177例)、多发斑块组(79例)、狭窄斑块组(102例),同时检测五组患者的血常规(计算NLR)和STB水平,并进行统计学分析。结果单因素分析显示,各组年龄、性别、体重指数(BMI)、糖尿病(DM)、糖化血红蛋白(Hb A1c)、NLR、STB、血红蛋白(HGB)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)比较均有统计学差异(P<0.05)。多分类Logistic回归分析显示,年龄、BMI、LDL-C、NLR和STB为EH患者颈动脉粥样硬化的独立危险因素。结论 EH患者颈动脉粥样硬化与NLR和STB水平关系密切。
Objective To study the relationship between serum total bilirubin (STB) level and neutrophil/lymphocyte ratio (NLR) and carotid atherosclerosis in patients with essential hypertension (EH). Methods Five hundred and seventy-one patients with EH detected by carotid uhrasonography were divided into smooth intima ( n = 95 ), thickened intima ( n = 118 ), a few plaques ( n = 177 ), multiple atheroscle- rosis plaques( n = 79)and stenotic plaques( n= 102)groups. Their blood routine and STB levels were detected and NLR were calculated. Resuits The ratio of diabetes, males, age, BMI, NLR , STB, TC, LDL-C, HbA1 c and HG.B of patients in the five groups had significant differences ( P = 0.011,0.018,0.000,0.001,0.005,0.005,0. 003,0. 004,0.015,0. 000, respectively). Multinomial logistic regression a- nalysis showed that age, BMI, LDL-C, NLR and STB were the independent risk factors of carotid atherosclerosis with EH. Conclusions STB level and NLR are correlated with carotid atherosclerosis in patients with EH.
作者
刘东凤
刘昌松
苏双
冯骞
林捷琪
吴赛珠
LIU Dong-Feng LIU Chang-Song SU Shuang et al(Nanfang Medical University, Nanfang Hospital, Guangzhou 510515, Guangdong, China)
出处
《中国老年学杂志》
CAS
北大核心
2017年第3期578-581,共4页
Chinese Journal of Gerontology
基金
国家"973"项目子课题(2007CB507404)
广东省科技计划项目(2010B031500013)