摘要
The pathological mechanisms associated with the trans-activating response DNA/RNA binding protein（TDP）-43 remain largely enigmatic.Accumulation,insolubility and post-translational modification of nuclear and cytoplasmic TDP-43 are evident in many neurodegenerative diseases.TDP-43 constitutes one of the major molecular pathologies associated with RNA metabolism.
The pathological mechanisms associated with the trans-activating response DNA/RNA binding protein（TDP）-43 remain largely enigmatic.Accumulation,insolubility and post-translational modification of nuclear and cytoplasmic TDP-43 are evident in many neurodegenerative diseases.TDP-43 constitutes one of the major molecular pathologies associated with RNA metabolism.
基金
supported by Georgetown University funding to Moussa CE.Moussa CE,M.D.,Ph.D.,is listed as an inventoron a pending U.S.patent application to use tyrosine kinase inhibitors as a treatment for neurodegenerative diseases
