淋巴瘤化疗患者癌因性疲乏与抑郁的相关性

Correlation analysis on cancer-related fatigue and depression in lymphoma patients receiving chemotherapy

目的探讨淋巴瘤化疗患者的癌因性疲乏水平与抑郁情绪的相关性。方法 2014年6月-2016年7月采用自制的一般情况调查表、癌症疲乏量表（CFS）和抑郁自评量表（SDS）对入住中国医科大学附属第一医院血液内科的150例进行化疗的淋巴瘤患者进行问卷调查,测量淋巴瘤化疗患者的癌因性疲乏量表得分和抑郁自评量表得分,并对得分进行相关分析。结果 患者癌因性疲乏的发生率为99.33%,总体疲乏得分为（23.18±8.06）分,各维度得分由高到低为躯体疲乏〉情感疲乏〉认知疲乏。患者抑郁发生率为66.77%,SDS得分为（42.26±7.04）分,明显高于国内常模（P〈0.01）。淋巴瘤化疗患者的癌因性疲乏总分、躯体维度、情感维度、认知维度得分均与抑郁总分呈正相关（r=0.587、0.462、0.494、0.352,均P〈0.01）。结论 淋巴瘤化疗患者癌因性疲乏的发生率较高,其中,躯体疲乏较情感疲乏和认知疲乏更为严重。淋巴瘤化疗患者抑郁发生率较高且较为严重。癌因性疲乏与抑郁呈正相关。临床工作人员应密切关注淋巴瘤化疗患者癌因性疲乏和抑郁情绪,及时评估并进行干预。

Objective To explore the relationship between the cancer-related fatigue and depression in lymphoma patients receiving chemotherapy. Methods A research was developed from June 2014 to July 2016 in the First Affiliated Hospital of China Medical University by adopting self-designed general information questionnaire, questionnaires of cancer fatigue scale （CFS） and the self-rating depressions scale （SDS）. 150 lymphoma patients receiving chemotherapy were investigated. The scores of the CFS and SDS were measued, and the correlations of the scores were analyzed. Results The CRF incidence in these patients was 99.33%, the total scores was （23.18±8.06） points, the scores of dimensions from high to low as follows：physical fatigue, affective fatigue and cognitive fatigue. The depression incidence in these patients was 66.7%, the scores of SDS [（42.26±7.04） points] were higer than the national norm （P 〈 0.01）. The total scores of CRF, the scores of physical fatigue, affective fatigue and cognitive fatigue in lymphoma patients receiving chemotherapy were correlated positively with the depression （r=0.587, 0.462, 0.494, 0.352, P 〈 0.01）. Conclusion The incidence rates of CRF and depression in lymphoma patients receiving chemotherapy are higher, physical fatigue is higer than affective fatigue and cognitive fatigue, and the CRF is positively related with patients＇ depression. Nurses should attach more attention to the assessment and intervention of the cancer-related fatigue and depression in lymphoma patients receiving chemotherapy.