人工流产后口服短效避孕药的临床研究

Clinical research of short-acting oral contraceptive after artificial abortion

目的探讨口服短效避孕药去氧孕烯炔雌醇片(妈富隆)在人工流产后的临床应用价值。方法 2000例自愿终止妊娠者,随机分为观察组和对照组,各1000例。观察组给予口服短效避孕药、中成药和抗生素,对照组给予口服中成药和抗生素。观察两组患者术后出血时间、出血量和月经恢复等情况。结果观察组阴道出血时间、月经恢复时间短于对照组,阴道出血量明显少于对照组(P<0.01)。观察组无一例再次妊娠,对照组有8例再次妊娠,比较差异有统计学意义(P<0.01)。观察组再次妊娠率明显低于对照组(P<0.01)。观察组的并发症发生率明显低于对照组(P<0.01)。术后2周,观察组雌激素(E2)、血清促卵泡刺激素(FSH)、黄体生成素(LH)水平均明显低于对照组(P<0.05)。结论人工流产后即时应用口服短效避孕药能缩短出血时间,减少阴道出血量,促进月经恢复,减少闭经和重复流产的发生,降低人工流产术后并发症,值得临床推广应用。

Objective To investigate clinical application value of desogestrel and ethinylestradiol tablets（Marvelon） as short-acting oral contraceptive after artificial abortion. Methods A total of 2000 women receiving voluntary pregnancy termination were randomly divided into observation group and control group, with 1000 cases in each group. The observation group received short-acting oral contraceptive, Chinese patent medicine and antibiotics, and the control group received Chinese patent medicine and antibiotics. Observation was made on postoperative bleeding time, bleeding volume and menstruation recovery in both groups. Results The observation group had shorter colporrhagia time, menstruation recovery time and much less bleeding volume than the control group（P〈0.01）. The observation group had no subsequent pregnancy case, while there were 8 subsequent pregnancy cases in the control group, and their difference had statistical significance（P〈0.01）. The observation group had obviously lower subsequent pregnancy rate than the control group（P〈0.01）. Incidence of complications was lower in the observation group than in the control group（P〈0.01）. In postoperative 2 weeks, the observation group had much lower estradiol（E2）, follicle-stimulating hormone（FSH） and luteinizing hormone（LH） levels than the control group（P〈0.05）. Conclusion Instant application of short-acting oral contraceptive after artificial abortion can shorten bleeding time, reduce colporrhagia volume, accelerate menstruation recovery, reduce amenorrhea and repeated abortion, and decrease complications after artificial abortion. This method is worth clinical promotion and application.