氨磺必利与利培酮治疗首发精神分裂症患者疗效的比较研究

Comparative study of Amisulpride and Risperidone in treatment of first-episode schizophrenia

目的:比较氨磺必利与利培酮治疗首发精神分裂症患者的疗效。方法:将80例首发精神分裂症患者随机分为氨磺必利组和利培酮组,每组各40例。氨磺必利组患者给予口服氨磺必利治疗;利培酮组患者则给予口服利培酮治疗。比较两组患者的总体治疗效果、精神分裂症状评分与药物不良反应等。结果:氨磺必利组患者的总体治疗效果明显优于利培酮组,组间存在明显差异(P<0.05);治疗后,氨磺必利组患者阳性症状、阴性症状、一般精神病理评分与总分均显著性低于利培酮组,存在显著性差异(P<0.01);氨磺必利组患者嗜睡与肌强直发生率明显高于利培酮组,组间存在明显差异,具有统计学意义(P<0.05)。结论:氨磺必利治疗首发精神分裂症患者的疗效较利培酮显著,但其嗜睡与肌强直不良反应显著高于利培酮。

Objective：To compare clinical efficacies of Amisulpride and Risperidone in treatment of first-episode schizophrenia.Methods：80 patients with first-episode schizophrenia patients were randomly divided into two groups：Amisulpride group was treated with oral administration of Amisulpride,while Risperidone treated group was orally taking Risperidone.The overall treatment effects,schizophrenia symptom score and drug side effects of the two groups were compared.Results：The overall curative effect of Amisulpride group was obviously superior to Risperidone group,and the difference was statistically significant（P〈0.05）.After the treatment,the scores of the positive symptoms,negative symptoms,general psychopathology a well as the total score of Amisulpride group were significantly lower than those of Risperidone group,and the differences were statistically significant（P〈0.01）;The incidence rates of sleepiness and myotonia of Amisulpride group were significantly higher than those of risperidone group,and the differences had the statistical significance（P〈0.05）.Conclusions：The curative effect of Amisulpride in the treatment of first-episode schizophrenia is more significant than Risperidone,but the incidence rates of sleepiness and myotonia are higher.