抗结核药物导致患者肝损害88例临床分析

Clinical analysis of 88 cases of liver damage caused by anti-tuberculosis drugs

目的：分析抗结核药物引起患者肝损害的因素。方法：回顾性分析确诊为继发性肺结核的88例初治患者,观察抗结核治疗后其肝功能损害情况。结果：88例患者平均年龄（49.08±17.49）岁;肝损害集中分布在40-69岁,多发生在服药3个月内;乙型肝炎表面抗原阳性患者32例,肝损害程度与抗原阴性者相比较重,有统计学差异。结论：年龄因素、乙肝病毒感染和药物因素是抗结核药引起患者肝功能损害的重要因素。

Objective：To analyze factors for liver damage caused by anti-tuberculosis drugs.Methods：88 first-treated patients with secondary pulmonary tuberculosis were retrospectively analyzed,and their liver function damages after anti-tuberculosis treatment were observed.Results：The average age of the 88 patients was 49.08±17.49 years old.Liver damage concentrated in those of 40-69 years,and frequently occurred in three months of medication.Hepatitis b surface antigen was positive in 32 cases,their liver damages were more severe than those with antigen negative,and there was a significant difference.Conclusions：Age,hepatitis b virus infection and drug factors play an important role in liver damage caused by anti-tuberculosis drugs.