血清肿瘤标志物检测在肺癌诊断中的临床价值研究

Clinical Value of Serum Tumor Markers in Diagnosis of Lung Cancer

目的探讨4种血清肿瘤标志物[癌胚抗原(CEA)、神经烯醇酶(NSE)、细胞角质蛋白(CYFRA11-1)、糖类抗原125(CA125)]检测在肺癌诊断中的临床价值。方法选取2014年5月—2016年7月宝鸡市中心医院收治的肺癌患者46例,作为肺癌组;另选取同时期收治的肺部良性肿瘤患者32例,作为良性肿瘤组。检测并比较两组患者血清CEJA、NSS、CYF.RA21-1、CA125水平,以及不同病理组织类型肺癌组间的血清肿瘤标志物阳性检测率。结果肺癌组患者血清CE:A、SSE、CYTRA21-1、CA125水平均高于良性肿瘤组(P<0.05)。腺癌患者的CEA阳性检测率高于鳞癌、小细胞癌(P<0.05);小细胞癌的NSE阳性检测率高于鳞癌、腺癌(P<0.05);鳞癌的CYFRA21-1阳性检测率高于小细胞癌(P<0.05);鳞癌、腺癌、小细胞癌的CA125阳性检测率比较,差异无统计学意义(P>0.05)。结论 CEA、NSE.CYFRA21-1及CA125对肺癌的诊断具有一定临床价值,建议多种指标联合检测,以提高肺癌的诊断准确率。

Objective To explore the clinical value of serum tumor markers （CEA, NSE, CYFRA21 - 1 , CA125 ） in diagnosis of lung cancer. Methods A total of 46 lung cancer patients were selected in Central Hospital of Baoji from May 2014 to July 2016 as lung cancer group; and in the same period, anthor 32 patients with benign lung tumors were selected as benign lung tumors group. The serum CEA, NSE, CYFRA21 - 1 , CA125 levels between the two groups were detected and compared, and the positive detection rate of serum tumor markers among different pathological types were compared. Results The serum CEA, NSE, CYFRA21 - 1 , CA125 levels of lung cancer group were statistically significantly higher than that of benign lung tumors group （P 〈0. 05）. The positive detection rate of serum CEA of adenocarcinoma was statistically significantly higher than that of adenocarcinoma and small cell carcinoma （P 〈 0. 05 ）. The positive detection rate of serum NSE of small cell carcinoma was statistically significantly higher than that of adenocarcinoma and squamous cell carcinoma （ P 〈 0. 05 ） . The positive detection rate of serum CYFRA21 - 1 of squamous cell carcinoma was statistically significantly higher than that of small cell carcinoma （P 〈 0. 05）. No statistically significant differences of positive detection rate of serum CA125 was found between adenocarcinoma, squamous cell carcinoma, and small cell carcinoma （P 〉 0. 05 ）. Conclusion CEA , NSE , CYFRA21 - 1 and CA125 in the diagnosis of lung cancer has a certain clinical value, it is recommended that a variety of indicators combined detection, to improve the accuracy of diagnosis of lung cancer.