环孢素联合雄性激素治疗非重型再生障碍性贫血的临床疗效观察

Clinical Effect of Cyclosporine Combined with Androgen in the Treatment of Patients with Non-severe Aplastic Anemia

目的探讨环孢素联合雄性激素治疗非重型再生障碍性贫血(NSAA)患者的疗效。方法回顾性选取2008—2015年临清市人民医院收治的非输血依赖的NSAA患者60例,根据治疗方法分为治疗组和对照组,治疗组患者给予环孢素联合雄性激素治疗,对照组单用环孢素治疗。治疗前检测两组患者血常规,记录治疗效果及不良反应。结果治疗前两组患者白细胞计数、血红蛋白、中性粒细胞计数、血小板计数、网织红细胞计数、红细胞平均体积比较,差异均无统计学意义(P>0.05)。两组患者治疗效果比较,差异有统计学意义(P<0.05)。中位随访30个月,仅对照组有1例患者进展为重型再生障碍性贫血,其余患者维持原疗效状态,两组患者不良反应均轻微。结论环孢素联合雄性激素治疗NSAA比单用环孢素疗效好,且不良反应轻微,临床应用安全。

Objective To investigate the clinical effect of cyclosporine combined with androgen in the treatment of patients with non - severe aplastic anemia （ NSAA ）. Methods 60 cases of non transfusion dependent NSAA patients in Linq ing People＇s Hospital from 2008 to 2015 were selected,were divided into treatment group and control group by treatment, 30 cases in each group. Cases in the treatment group were treated with cyclosporine combined with androgen, cases in the control group were treated with cyclosporine. The routine blood was tested before treatment in two groups. Recorded the therapeutic effect and adverse reaction. Results The differences of WBC , Hb , neutrophil count, platelet count, reticulocyte count, average red blood cell volume before treatment between two groups were statistically significant （P 〉 0. 05 ）. The difference of therapeutic effect between two groups was statistically significant （P 〈 0. 05 ）. Follow - up of 30 months, there was one case of patients with severe aplastic anemia in the control group, and the remaining patients to maintain the original curative effect, two groups of patients with adverse reactions were mild . Conclusion Cyclosporine combined with androgen in the treatment of NSAA patients is better than the single use of cyclosporine, and the adverse reaction is mild , it can be safely used clinically .