微波联合前列舒通胶囊治疗慢性非细菌性前列腺炎的临床疗效及其对白介素8和肿瘤坏死因子α的影响

Clinical Effect of Microwave Combine with Prostate Soothing Capsule in Treating Chronic Abacterial Prostatitis and Its Influence on IL-8 and TNF-α

目的探讨微波联合前列舒通胶嚢治疗慢性非细菌性前列腺炎(CAP)的临床疗效及其对白介素8(IL-8)和肿瘤坏死因子α(TNF-α)的影响。方法选取河西学院附属张掖人民医院收治的CAP患者60例,随机分为观察1组和观察2组,各30例;另选取同时期在本院体检的健康成年人20例,作为对照组。观察1组患者口服普乐安片;观察2组患者口服前列舒通胶嚢,同时接受微波治疗。比较两观察组患者的临床疗效和不良反应发生情况,以及3组的前列腺液(EPS)中IL-8和TNF-α水平。结果观察2组患者临床疗效优于观察1组(P<0.05)。治疗前,观察1组和观察2组患者EPS中IL-8和TNF-α水平高于对照组;而观察1组和观察2组患者比较,差异无统计学意义(P>0.05)。治疗后,观察1组患者EPS中IL-8和TNF-α水平高于观察2组和对照组(P<0.05);而观察2组和对照组患者比较,差异无统计学意义(P>0.05)。两组患者均未出现因口服药物引发的明显不良反应,观察2组患者中,因微波治疗引发肛门不适、排便感2例。结论微波联合前列舒通胶嚢治疗CAP的临床疗效确切,可明显降低患者EPS中IL-8和TNF-α水平。

Objective To explore the clinical effect of microwave combine with prostate soothing capsule in treating chronic abacterial prostatitis （ CAP） and its influence on IL - 8 and TNF - α. Methods A total of 60 CAP patients were selected in Zhangye Peopled Hospital Affiliated to Hexi University, and they were divided into observation - 1 group and observation - 2 group. Another 20 healthy adult accepted physical examination during the same time were selected as control group. The observation - 1 group were treated with oral pulean tablets, while observation - 2 group were treated with oral prostate soothing capsule and the treatment of microwave. The clinical effect and adverse reaction conditions between the two observation group, and the IL - 8, TNF - α levels in EPS among the three groups were compared. Results The clinical effect of observation -2 group was statistically significantly better than that of observation - 1 group （P 〈 0. 05 ）. Before treatment, the IL-8 and TNF - α levels in EPS of the two observation groups were statistically significantly higher than that of control group （P 〈 0. 05） ; while no statistically significant differences of the IL-8 or TNF - α level in EPS was found between observation - 1 group and observation - 2 group （P 〉 0. 05 ）. After treatment, the IL-8 and TNF -α levels in EPS of observation - 1 group were statistically significantly higher than that of observation - 2 group and control group （ P 〈 0. 05 ） ; while no statistically significant differences of the IL-8 or TNF - α level in EPS was found between observation - 2 group and control group （P 〉 0. 05）. No significant adverse reactions that due to oral drug were appear in the two observation groups, 2 cases of anal discomfort and defecation due to microwave treatment in observation - 2 group. Conclusion The clinical effect of microwave combine with prostate soothing capsule in treating CAP is exactly, and it can effectively reduce the IL-8 and TNF - α levels in EPS.