用于骨修复的羧甲基纤维素增强半水硫酸钙复合材料研究

Carboxymethyl Cellulose Reinforced Calcium Sulfate Hemihydrate Composite for Bone Repair

以羧甲基纤维素增强半水硫酸钙,使其更适合应用于骨修复。通过抗压性能测试确定了优化的纤维用量,纤维比例为3%时抗压能力约为42 MPa。借助X射线衍射和电镜扫描分析手段,探索了纤维用量对基质结晶种类和纤维分布的影响,结果表明纤维用量过多将导致分散不均、易产生二水硫酸钙而影响强度。通过磷酸缓冲盐溶液培养测试证明,加入羧甲基纤维素后半水硫酸钙的耐溃散性能得到显著提高。

The carboxymethyl cellulose were used to reinforce calcium sulfate hemihydrates（ CSH） to make it more suitable for bone repair. The compressive strength of the composites was evaluated and an optimistic fiber level was concluded. When 3% cellulosic fiber was added to CSH the resulted composite could stand 42 MPa compressive force. By using X-ray diffraction scans and electric scan microscope,the crystal of CSH and distribution of fibers were analyzed. Excessive fibers resulted in the uneven distribution in CSH matrix and creation of calcium sulfate dihydrate, which would decrease the compressive strength of the composites. The result of soaking samples in phosphate buffer solution proved that the anti-washout of CSH obviously improved when carboxymethyl cellulose were introduced.