XBP-1在肿瘤发生发展中的研究进展

The transcription factor X-box binding protein-1 in tumorigenesis and development of cancer

X-盒结合蛋白1(X-box binding protein 1,XBP-1)是一种新近发现的与蛋白质折叠和内质网构建相关的蛋白质,研究发现其在多种肿瘤细胞中均有广泛表达,与肿瘤发生、发展的关系密切。本文对XBP-1参与肿瘤发生、发展过程的免疫逃避、血管生成、缺氧、侵袭转移等方面的研究进展做一综述。

X - box binding protein - 1 （ XBP - 1 ） is a newly found protein that plays significant roles in protein folding and endoplasmic reticulum construction. The expression of XBP - 1 is widely displayed in various kinds of tumor and is shown to take part in tumorigenesis and tumor progression. This review briefly summarizes the biology of XBP - 1 and focuses on recent findings concerning its role in immune evasion,tumorigenesis,devel-opment of cancer,angiogenesis,hypoxia,invasion and metastasis.