生长抑素结合早期肠内营养对重症急性胰腺炎患者治疗效果观察

Clinical effect of somatostatin combined with early enteral nutrition therapy for patients with severe acute pancreatitis

目的探讨生长抑素结合早期肠内营养对重症急性胰腺炎患者的治疗效果。方法选取62例重症胰腺炎患者随机分为观察组和对照组,分别给予生长抑素结合早期肠内营养或常规治疗,比较两组患者临床疗效、血、尿淀粉酶恢复时间、腹胀、腹痛、呕吐、发热消失时间及并发症发生情况。结果观察组的临床总有效率为93.55%,较对照组的80.65%显著提高(P<0.05);治疗后血淀粉酶恢复时间、尿淀粉酶恢复时间、住院时间均较对照组显著缩短(P<0.05);腹胀、腹痛、呕吐、发热消失时间均较对照组显著缩短(P<0.05);观察组的并发症发生率为9.68%,较对照组的32.26%显著降低(P<0.05)。结论生长抑素结合早期肠内营养治疗重症急性胰腺炎可显著提高临床疗效,降低并发症发生率,值得进一步在临床上推广。

Objective To analyze the effect of somatostatin combined with earlyenteral nutrition therapy for patientswith severe acute pancreatitis. Methods Sixty two patients with severe acute pancreatitis were randomly divided into observation group and control group. Patients in observation group were treated with somatostatin combined with early enteral nutrition, while patients in control group were givenconventional treatment. The clinical efficacy, blood and urine amylase recovery time, bloating, abdominal pain, vomiting, fever disappearance time and occurrence of complications were evaluated and compared. Results The clinical effective rate of observation group was significantly higher thancontrol group （93.55% vs. 80.65%, P 〈 0.05）. The serum and urine amylase recovery time, and hospital stay were significantly shortened in observation group than in control group （P 〈 0.05）. The bloating, abdominalpain, vomiting, fever disappearance time were significantly shortened in observation group than in control group （P 〈 0.05）. The complication rate of observation group was significantly lower compared with the control group （9.68% vs. 32.26% P 〈 0.05）. Conclusion Somatostatin combined with early enteral nutrition therepy could significantly improve the clinical efficacy and reduce the incidence of complications inpatients with severe acute pancreatitis.