调肾保心法对冠心病心绞痛二级预防的队列研究

Kidney-adjusting and Heart-protecting Therapy on the Secondary Prevention of Coronary Heart Disease with Angina Pectoris:a Cohort Study

目的探讨调肾保心法中药对冠心病心绞痛二级预防的作用。方法将80例受试者随机分为暴露组和未暴露组,暴露组采用西医基础治疗并服用孙兰军教授调肾保心法汤药,未暴露组只采用西医基础治疗。观察比较两组心绞痛分级变化、西雅图量表评分、心肌梗死发生率、再住院率及死亡率。结果心绞痛分级变化,暴露组优于未暴露组。西雅图量表评分,暴露组较未暴露组有优势。两组心肌梗死发生率、再住院率及死亡率比较差异无统计学意义,但随着随访时间的延长,暴露组累积无心脏事件发生率较未暴露组有增高趋势。结论调肾保心法对冠心病心绞痛有较好的治疗作用,对其二级预防有促进作用。

Objective To investigate the effect of kidney-adjusting and heart-protecting therapy on the secondary prevention of angina pectoris.Methods Eighty patients with angina pectoris were randomly divided into two groups：non-exposed group treated with basic treatment of western medicine,and exposed group treated with basic treatment of western medicine plus kidney-adjusting and heartprotecting therapy.The changes of angina pectoris,the scores of Seattle Angina Questionnaire（SAQ）,the incidence rate of myocardial infarction,re hospitalization rate and mortality rate were observed.Results The level of angina pectoris was changed,which was better in exposure group than that of the non-exposed group.The scores of SAQ in exposure group were better than that in non-exposed group.There was no significant difference in the incidence of myocardial infarction,re hospitalization rate and mortality between two groups.However,with the extension of follow-up time,there was an increasing trend of the incidence of cardiac events in exposed group.Conclusion Kidney-adjusting and heart-protecting therapy has the curative effect and better prevention on angina pectoris of coronary heart disease.