参附注射液联合常规疗法治疗心衰的临床疗效分析

Clinical Effect of shenfu injection combined with conventional therapy on heart failure

目的探讨参附注射液联合常规疗法治疗心衰的疗效,通过对NT-proBNP水平变化监测,了解心力衰竭患者预后情况。方法随机将50例心衰患者分为两组,常规治疗组25例,联合参附注射液治疗组25例。每例患者治疗前检查N端脑钠肽前体(N-terminal pro-Brain Natriuretic Peptide,NT-proBNP),记录数据。然后分别予常规治疗及联合参附注射液治疗10 d。再次复查NT-proBNP,同时记录患者的住院天数及预后情况。结果治疗后,常规治疗组及参附注射液治疗组NT-proBNP均明显下降,两组治疗均有效,且组间比较,差异具有统计学意义(t=3.29,P<0.05)。治疗后,常规治疗组平均住院(17.80±3.65)d,参附注射液治疗组平均住院(13.50±2.26)d,两组住院天数比较具有统计学差异(P<0.05)。结论参附注射液联合常规心衰治疗有助于患者改善病情,缩短住院时间,具有积极的临床意义。

Objective To investigate the therapeutic effect of shenfu injection combined with routine treatment in heart failure,and to evaluate the prognosis for recovery of patients with heart failure by monitoring the change of NT-proBNP level. Methods The patients with heart failure were randomly divided into two groups including the conventional treatment group and the shenfu injection treatment group,with 25 cases in each group.N-terminal pro-brain natriuretic peptide（N-terminal pro-brain natriuretic peptide） of each patient was recorded into the data before treatment.Then the routine treatment and the routine treatment combined with shenfu injection treatment were given to the two groups for 10 days,respectively. And NT-proBNP was reexamined, the prognosis and the hospitalization days was compared between the two groups. Results The average levels of brain natriuretic peptide significantly decreased in treatment group and shenfu injection group, indicating efficacy in both treatment groups, and the difference between two groups was smaller.The means bteween the two groups were compared after treatment, and the difference was statistically significant（t=3.29,P〈0.05）. After treatment, the average length of hospital stay of the routine treatment group was（17.80±3.65）d, the average length of hospital stay days in Shenfu injection group was（13.50± 2.26）d,the mean number of days of hospitalization between the two groups was statistically significant（P〈0.05）. Conclusion Shenfu injection combined with conventional treatment in threatment of heart failure can improve the condition and shorten the length of hospitalization, with a positive clinical significance.