替加环素致胆红素水平升高

Elevation of serum bilirubin level due to tigecycline

1例74岁男性患者因小肠憩室伴穿孔术后发生感染性休克，静脉滴注替加环素50 mg/12 h。用药前TBil 11.1 μmol/L，DBil 2.3 μmol/L，间接胆红素（IBil） 8.2 μmol/L。用药第4天，患者TBil 99.1 μmol/L，DBil 48.1 μmol/L，IBil 32.3 μmol/L；第6天，患者皮肤出现黄染，TBil 206.3 μmol/L，DBil 126.7 μmol/L，IBil 45.4 μmol/L。停用替加环素。停药后第4天，患者TBil 167.4 μmol/L，DBil 98.2 μmol/L，IBil 36.1μmol/L。2周后电话随访，患者TBil 18.3 μmol/L，DBil 3.4 μmol/L，IBil 11.6 μmol/L。

A 74 year old male patient received an IV infusion of tigecycline 50 mg per 12 hours because of septic shock induced by diverticulum of small intestine complicated with perforation after surgery. Before IV infusion, the results of laboratory test showed the following valumes： total bilirubin （TBil） 11.1 μmol/L, direct bilirubin （DBil） 2.3 μmol/L, indirect bilirubin （IBil） 8.2 μmol/L. On day 4 of drug administration, the results of laboratory test showed the following volumes： TBil 99.1 μmol/L, DBil 48.1 μmol/L, IBil 32.3 μmol/L. On day 6 of drug administration, the patient developed yellow scle, the results of laboratory test showed the following volumes： TBil 206.3 μmol/L, DBil 126.7 μmol/L, IBil 45.4 μmol/L. Tigecycline was stopped. On day 4 of drug withdrawal, the results of laboratory test were TBil 167.4 μmol/L, DBil 98.2 μmol/L, IBil 36.1μmol/L. Two weeks later, TBil was 18.3μmol/L, DBil 3.4 μmol/L, IBil 11.6μmol/L.