注射用脂溶性维生素（Ⅱ）致患儿药物热和皮疹

Fever and rash due to fat-soluble vitamins （ Ⅱ ） in a child

1例9岁女性患儿畸胎瘤切除术后给予头孢呋辛1.5 g静脉滴注、1次/12 h，注射用脂溶性维生素（Ⅱ）1支、1次/d和注射用水溶性维生素10 ml、1次/d。首次输注脂溶性维生素液和水溶性维生素时出现轻度胸闷和烦躁；每次输注后1～3 h，患儿体温明显升高。第4天，患儿颜面部、耳后、躯干部出现红色点片状斑丘疹，逐渐发展至四肢和手足。停用注射用脂溶性维生素（Ⅱ），注射用水溶性维生素继续应用。12 h后，患儿体温恢复正常，皮疹减少。次日皮疹消失。

A 9-year-old girl received intravenous infusions of cefuroxime 1.5 g twice daily, fat-soluble vitamins （Ⅱ） 1 bottle once daily and water-soluble vitamin 10 ml once daily after resection of teratoma. Mild chest tightness and irritability appeared after the first infusion of fat-soluble vitamin and water-soluble vitamin. One to three hours after each infusion, her body temperature significantly increased. On day 4, erythematous spotted and patchy maculopapular rashes occurred on her face, ear, trunk, and gradually extended developed to the limbs, hand and foot. Fat-soluble vitamins （Ⅱ） was stopped, and water-soluble vitamins were continued to use. The patient′ body temperature returned to normal and the rash gradually reduced after 12 hours. On the following day, the rash disappeared.