疏肝和胃饮辨证加减治疗肝胃不和型胆汁反流性胃炎疗效观察

Therapeutic effect of Shugan Hewei decoction reflux gastritis with incoordination between the liver and stomach bile treatment dialectical addition and subtraction

目的:探讨疏肝和胃饮加减在肝胃不和型胆汁反流性胃炎(PBRG)治疗中的应用价值及作用机制。方法:以82例肝胃不和型PBRG患者作为观察对象,随机将所有观察对象分为两组,其中接受西药治疗者为对照组,接受中药疏肝和胃饮加减治疗者为研究组,每组41例。对比两组临床症状改善情况、治疗效果及胃黏膜胃动素(MTL)及血管活性肠肽(VIP)变化情况。结果:4周治疗完成后,研究组中医症状积分及GERD-HRQL积分低于对照组(P<0.05)。同时,研究组不良反应发生率低于对照组(P<0.05)。此外,完成4周治疗后,研究组MTL高于对照组,VIP低于对照组,具统计学差异。结论:肝胃不和型PBRG治疗中疏肝和胃饮加减同样具有着较为理想的治疗效果,且其治疗机制可能与改善胃黏膜MTL及VIP有关。

Objective：To investigate the application value and function mechanism of Shugan Hewei decoction in PBRG.Methods：82patients with ganweibuhe PBRG patients were randomly divided into two groups,received western medicine treatment for control group,received traditional Chinese medicine of Shugan Hewei decoction as study group,41 in each group.Comparison the clinical symptoms,treatment effect,MTL and VIP of two groups.Results：After 4weeks treatment,the TCM symptom and GERD-HRQL score in study group were lower than control group（P〈0.05）.And the incidence of adverse reaction in the study group was lower than control group（P〈0.05）.In addition,after 4weeks of treatment,the study group MTL higher than the control group,VIP lower than the control group（P〈0.05）.Conclusion：PBRG treatment of Shugan Hewei decoction has a good treatment effect,and its therapeutic mechanism may be related to the improvement of MTL and VIP on gastric mucosa.